Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6A5_HUMAN
Description:ribosomal protein S6 kinase, 90kDa, polypeptide 5 [Source:HGNC Symbol;Acc:10434]
Location:chr14 q32.11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S376LFQGYsFVAPSRSK-5phosphoELM; SysPTM
T581NQPLKtPCFTLErk2RegPhos
T581NQPLKtPCFTLErk1RegPhos
S360MDPTYsPAALPMAPK14phosphoELM
S212TERAYsFCGTIMSK1(RSK5RegPhos
S752KKTSTsTETRSPhosphoSitePlus
S376LFQGYsFVAPSPkinase_CPhosphoSitePlus; SysPTM
T700SNPLMtPDILGPhosphoSitePlus
S360MDPTYsPAALPErk1(MAPK3RegPhos
S381SFVAPsILFKRHPRD
T751MKKTStSTETRPhosphoSitePlus
S360MDPTYsPAALPPkinase_CPhosphoSitePlus
S376LFQGYsFVAPSMSK1(RSK5RegPhos; SysPTM
S376LFQGYsFVAPSautocatalysisRegPhos; SysPTM
S376LFQGYsFVAPSErk2RegPhos; SysPTM
S381SFVAPsILFKRPkinase_CPhosphoSitePlus
S695GSQLSsNPLMTPhosphoSitePlus
S760TRSSSsESSHSPhosphoSitePlus
S758TETRSsSSESSautocatalysisRegPhos
Y683MSGLRyNEWLQPkinasePhosphoSitePlus
S750KMKKTsTSTETRSK-5phosphoELM
S360MDPTYsPAALPMAPK3phosphoELM
S694DGSQLsSNPLMPhosphoSitePlus
T38RTANLtGHAEKPhosphoSitePlus
S212TERAYsFCGTIautocatalysisRegPhos
S381SFVAPsILFKRautocatalysisRegPhos
S376LFQGYsFVAPSphosphoELM; SysPTM
T581NQPLKtPCFTLErk1(MAPK3RegPhos
Y375KLFQGySFVAPPkinase_CPhosphoSitePlus
S758TETRSsSSESSPhosphoSitePlus
T581NQPLKtPCFTLErk2(MAPK1RegPhos
S212TERAYsFCGTIPkinasePhosphoSitePlus
S752KKTSTsTETRSautocatalysisRegPhos
S691WLQDGsQLSSNPhosphoSitePlus
S376LFQGYsFVAPSMAPK14HPRD; SysPTM
S381SFVAPsILFKRRSK-5phosphoELM
S376LFQGYsFVAPSp38aRegPhos; SysPTM
T581NQPLKtPCFTLPkinasePhosphoSitePlus
S759ETRSSsSESSHPhosphoSitePlus
S376LFQGYsFVAPSErk1RegPhos; SysPTM
S758TETRSsSSESSRSK-5phosphoELM
Y60LGTGAyGKVFLPkinasePhosphoSitePlus
S212TERAYsFCGTIRSK-5phosphoELM
S766ESSHSsSSHSHPhosphoSitePlus
T581NQPLKtPCFTLp38a(MAPK14RegPhos
T581NQPLKtPCFTLMAPK3HPRD; phosphoELM
T581NQPLKtPCFTLMAPK1HPRD; phosphoELM
S750KMKKTsTSTETPhosphoSitePlus
S376LFQGYsFVAPSMAPK3HPRD; SysPTM
S376LFQGYsFVAPSMAPK1HPRD; SysPTM
T581NQPLKtPCFTLp38aRegPhos
T793SNNPEtLFQFSPhosphoSitePlus
T581NQPLKtPCFTLMAPK14HPRD; phosphoELM
S752KKTSTsTETRSRSK-5phosphoELM
S750KMKKTsTSTETMSK1(RSK5RegPhos
S750KMKKTsTSTETautocatalysisRegPhos
S381SFVAPsILFKRMSK1(RSK5RegPhos
S758TETRSsSSESSMSK1(RSK5RegPhos
S360MDPTYsPAALPErk2(MAPK1RegPhos
S360MDPTYsPAALPMAPK1phosphoELM
S752KKTSTsTETRSMSK1(RSK5RegPhos
S360MDPTYsPAALPp38a(MAPK14RegPhos
S757STETRsSSSESPhosphoSitePlus

Dephosphorylation site
KS6A5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261991A327DCOSMICSkin Cancer21984974
ENSP00000261991A327DCOSMICSkin Cancer21984974
ENSP00000261991S263CCOSMICOvarian Cancer21720365
ENSP00000261991G609VCOSMICBreast Cancer20668451

Differential expressed protein
KS6A5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KS6A5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A5_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANKS6A5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KS6A5_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANH31T_HUMANkinase -> substrateRegPhos
MK01_HUMANKS6A5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KS6A5_HUMANTF65_HUMANkinase -> substrateRegPhos; NetPath
KS6A5_HUMANXPA_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANH2A1_HUMANkinase -> substrateRegPhos
KS6A5_HUMANNR4A1_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANPA24A_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMAN4EBP1_HUMANkinase -> substrateRegPhos
KS6A5_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANHMGN1_HUMANkinase -> substrateRegPhos
KS6A5_HUMANH2A3_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANKS6A5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KS6A5_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANETV1_HUMANkinase -> substrateRegPhos
KS6A5_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANSTK11_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANATF1_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANTY3H_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANBAD_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANRXRG_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANKS6A5_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05219Bladder cancer
hsa04722Neurotrophin signaling pathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0001818negative regulation of cytokine productionTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005634nucleusIMPcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0043987histone H3-S10 phosphorylationIMPbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0006950response to stressIEPbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0032793positive regulation of CREB transcription factor aTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016572histone phosphorylationTASbiological_process
GO:0004674protein serine/threonine kinase activityIMPmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0009605response to external stimulusIEPbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0043990histone H2A-S1 phosphorylationIDAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005840ribosomeIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0033129positive regulation of histone phosphorylationIMPbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0035066positive regulation of histone acetylationIMPbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0043988histone H3-S28 phosphorylationIMPbiological_process