Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TY3H_HUMAN
Description:tyrosine hydroxylase [Source:HGNC Symbol;Acc:11782]
Location:chr11 p15.5
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S71IGRRQsLIEDAHPRD; RegPhos
S40GAPGPsLTGSPPKACaRegPhos
S58TPTPRsPRFIGHPRD
S19FRRAVsELDAKCaMK2gRegPhos
S19FRRAVsELDAKCaMK2_groupRegPhos
S19FRRAVsELDAKMAPKAPK2HPRD; phosphoELM; RegPhos
S431LLHCLsEEPEIHPRD
S62TPTPRsPRFIGTOH_NPhosphoSitePlus
S435LLHCLsEEPEIRegPhos
S40GAPGPsLTGSPPRKACAHPRD
Y230FSDQVyRQRRKBiopterin_HPhosphoSitePlus
S19FRRAVsELDAKCaMK2aRegPhos
S40GAPGPsLTGSPMSK1RegPhos
S71IGRRQsLIEDACaMK2aRegPhos
S71IGRRQsLIEDACaM-KII_alphaphosphoELM
S19FRRAVsELDAKTOH_NPhosphoSitePlus
S67IGRRQsLIEDAHPRD
S31AEAIMsPRFIGHPRD
S40GAPGPsLTGSPRPS6KA5HPRD
S19FRRAVsELDAKphosphoELM; RegPhos
S71IGRRQsLIEDATOH_NPhosphoSitePlus
S19FRRAVsELDAKCaM-KII_groupphosphoELM
S19FRRAVsELDAKCAMK2GHPRD
S40IGRRQsLIEDAHPRD
S40GAPGPsLTGSPMAPKAPK2HPRD; phosphoELM; RegPhos
S36GAPGPsLTGSPPRKACAHPRD
S71IGRRQsLIEDAPKA_groupphosphoELM; RegPhos
S404LLHCLsEEPEIHPRD
S19FRRAVsELDAKCaM-KII_alphaphosphoELM
S62TPTPRsPRFIGHPRD; RegPhos
S40GAPGPsLTGSPphosphoELM; RegPhos
S40GAPGPsLTGSPPKA_groupRegPhos

Dephosphorylation site
TY3H_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000370571*529WCOSMICMelanoma21499247
ENSP00000370567G424WBIOMARTBreast Cancer21930507, 21930502
ENSP00000370571S509FCOSMICSkin Cancer21984974
ENSP00000370571*529WCOSMICMelanoma21499247
ENSP00000325951G397WBIOMARTBreast Cancer21930507, 21930502
ENSP00000370571G428WBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TY3H_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TY3H_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TY3H_HUMANDRD5_HUMANligand -> receptorHPMR
TY3H_HUMANDRD3_HUMANligand -> receptorHPMR
TY3H_HUMANDRD4_HUMANligand -> receptorHPMR
TY3H_HUMANDRD1_HUMANligand -> receptorHPMR
TY3H_HUMANDRD2_HUMANligand -> receptorHPMR
KCC2G_HUMANTY3H_HUMANkinase -> substrateHPRD
KCC4_HUMANTY3H_HUMANkinase -> substrateRobert H Newman (2013)
MAPK2_HUMANTY3H_HUMANkinase -> substrateRegPhos
KPCA_HUMANTY3H_HUMANkinase -> substrateHPRD
ZAGL2_HUMANTY3H_HUMANkinase -> substrateRegPhos
KS6A5_HUMANTY3H_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05034Alcoholism
hsa05012Parkinson's disease
hsa00350Tyrosine metabolism
hsa04728Dopaminergic synapse
hsa05031Amphetamine addiction
hsa05030Cocaine addiction
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0052314phytoalexin metabolic processIEAbiological_process
GO:0004511tyrosine 3-monooxygenase activityIDAmolecular_function
GO:0009887organ morphogenesisISSbiological_process
GO:0030424axonIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0007601visual perceptionIEAbiological_process
GO:0045472response to etherIEAbiological_process
GO:0042418epinephrine biosynthetic processIDAbiological_process
GO:0030659cytoplasmic vesicle membraneIEAcellular_component
GO:0051602response to electrical stimulusIEAbiological_process
GO:0046684response to pyrethroidIEAbiological_process
GO:0071312cellular response to alkaloidIEAbiological_process
GO:0006585dopamine biosynthetic process from tyrosineNASbiological_process
GO:0034617tetrahydrobiopterin bindingIEAmolecular_function
GO:0043473pigmentationTASbiological_process
GO:0005790smooth endoplasmic reticulumIDAcellular_component
GO:0007626locomotory behaviorISSbiological_process
GO:0007613memoryIEAbiological_process
GO:0010043response to zinc ionIEAbiological_process
GO:0009898internal side of plasma membraneIDAcellular_component
GO:0045471response to ethanolIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0016137glycoside metabolic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0001666response to hypoxiaIDAbiological_process
GO:0007612learningIEAbiological_process
GO:0035094response to nicotineIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0016597amino acid bindingIEAmolecular_function
GO:0042462eye photoreceptor cell developmentISSbiological_process
GO:0008016regulation of heart contractionISSbiological_process
GO:0004497monooxygenase activityIEAmolecular_function
GO:0043005neuron projectionIDAcellular_component
GO:0048596embryonic camera-type eye morphogenesisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0009416response to light stimulusIEAbiological_process
GO:0010259multicellular organismal agingIEAbiological_process
GO:0010038response to metal ionIEAbiological_process
GO:0007613memoryISSbiological_process
GO:0009414response to water deprivationIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0008198ferrous iron bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0015842synaptic vesicle amine transportIEAbiological_process
GO:0035240dopamine bindingIEAmolecular_function
GO:0048545response to steroid hormone stimulusIEAbiological_process
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0008021synaptic vesicleIEAcellular_component
GO:0031667response to nutrient levelsIEAbiological_process
GO:0048596embryonic camera-type eye morphogenesisISSbiological_process
GO:0042136neurotransmitter biosynthetic processIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0018963phthalate metabolic processIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0014823response to activityIEAbiological_process
GO:0019825oxygen bindingIEAmolecular_function
GO:0035690cellular response to drugIEAbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0050890cognitionIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0071287cellular response to manganese ionIEAbiological_process
GO:0006665sphingolipid metabolic processIEAbiological_process
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0003007heart morphogenesisNASbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0001963synaptic transmission, dopaminergicISSbiological_process
GO:0007605sensory perception of soundIEAbiological_process
GO:0008199ferric iron bindingIEAmolecular_function
GO:0042416dopamine biosynthetic processIDAbiological_process
GO:0043204perikaryonISScellular_component
GO:0001975response to amphetamineIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0007612learningISSbiological_process
GO:0009635response to herbicideIEAbiological_process
GO:0070848response to growth factor stimulusIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0007617mating behaviorIEAbiological_process
GO:0017085response to insecticideIEAbiological_process
GO:0042423catecholamine biosynthetic processTASbiological_process
GO:0007507heart developmentISSbiological_process
GO:0071316cellular response to nicotineIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0043195terminal buttonIEAcellular_component
GO:0016714oxidoreductase activity, acting on paired donors, IEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0009651response to salt stressIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035176social behaviorIEAbiological_process
GO:0006585dopamine biosynthetic process from tyrosineIEAbiological_process
GO:0033076isoquinoline alkaloid metabolic processIEAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0008016regulation of heart contractionIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0042421norepinephrine biosynthetic processIDAbiological_process
GO:0005634nucleusISScellular_component
GO:0007507heart developmentIEAbiological_process
GO:0042214terpene metabolic processIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0033162melanosome membraneIDAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0042755eating behaviorIEAbiological_process
GO:0007601visual perceptionISSbiological_process
GO:0045471response to ethanolIDAbiological_process
GO:0043204perikaryonIEAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0042462eye photoreceptor cell developmentIEAbiological_process
GO:0042745circadian sleep/wake cycleIEAbiological_process