Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H2A1_HUMAN
Description:histone cluster 1, H2ak [Source:HGNC Symbol;Acc:4726]
Location:chr6 p22.1
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2MSGRGkQMSK1(RSK5RegPhos
T121LLPKKtESHHKPhosphoSitePlus; RegPhos
T102LLGKVtIAQGGPhosphoSitePlus
S2MSGRGkQRegPhos
S2RGKQRSK-5phosphoELM
S123PKKTEsHHKAKPhosphoSitePlus
S2____MsGRGKQPhosphoSitePlus

Dephosphorylation site
H2A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352119G3VTCGAOvarian Cancer21720365, 18772890
ENSP00000352119G3VCOSMICOvarian Cancer21720365
ENSP00000352627M1VCOSMICOvarian Cancer21720365
ENSP00000352627Q7HCOSMICOvarian Cancer21720365
ENSP00000330307N69DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000330307E122DCOSMICHead and Neck Cancer21798897

Differential expressed protein
H2A1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
H2A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A5_HUMANH2A1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANH2A1_HUMANkinase -> substrateRegPhos
E2F1_HUMANH2A1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0006334nucleosome assemblyIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0000786nucleosomeIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function


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