| UniProt/SwissProt ID: | H2A3_HUMAN |
| Description: | histone cluster 3, H2a [Source:HGNC Symbol;Acc:20507] |
| Location: | chr1 q42.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2 | MSGRGkQ | RegPhos | |
| S2 | RGKQ | RPS6KA5 | HPRD |
| S2 | MSGRGkQ | MSK1 | RegPhos |
| S123 | PKKTEsHHKAK | PhosphoSitePlus | |
| S2 | ____MsGRGKQ | PhosphoSitePlus | |
| T102 | LLGRVtIAQGG | PhosphoSitePlus | |
| T121 | LLPKKtESHHK | PhosphoSitePlus; RegPhos | |
| Dephosphorylation site |
| H2A3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| H2A3_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000355656 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.41 | 19610612 |
| Hyperphosphorylation site |
| H2A3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | H2A3_HUMAN | kinase -> substrate | RegPhos |
| KS6A5_HUMAN | H2A3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05322 | Systemic lupus erythematosus |
| hsa05034 | Alcoholism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000786 | nucleosome | IEA | cellular_component |
| GO:0006334 | nucleosome assembly | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |