Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H33_HUMAN
Description:H3 histone, family 3A [Source:HGNC Symbol;Acc:4764]
Location:chr1 q42.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S32RKSAPsTGGVKPhosphoSitePlus; phosphoELM; RegPhos
T4__MARtKQTARPhosphoSitePlus
S29KAARKsAPSTGAurB(Aurora BRegPhos
S29KAARKsAPSTGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S58RRYQKsTELLIHistonePhosphoSitePlus
T108GLFEDtNLCAIHistonePhosphoSitePlus
S11QTARKsTGGKAPhosphoSitePlus; HPRD; RegPhos
T12TARKStGGKAPRegPhos
T81AQDFKtDLRFQHistonePhosphoSitePlus
S11QTARKsTGGKAAurB(Aurora BRegPhos
S29KAARKsAPSTGJNK2RegPhos
S29KAARKsAPSTGMAPK9HPRD
S29KAARKsAPSTGAurora BphosphoELM
S11QTARKsTGGKAAurora BphosphoELM
Y42KKPHRyRPGTVPhosphoSitePlus
T4MARTKqTARRegPhos
Y55REIRRyQKSTEPhosphoSitePlus
S87DLRFQsAAIGAHPRD
T46RYRPGtVALREPhosphoSitePlus

Dephosphorylation site
H33_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254810F105LCOSMICOvarian Cancer20826764
ENSP00000355778R3CCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000254810Uterine CancerNormal vs. CancertissueUp17902640

Hyperphosphorylation site
H33_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANH33_HUMANkinase -> substrateRegPhos
AURKB_HUMANH33_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANH33_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05202Transcriptional misregulation in cancer
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0006334nucleosome assemblyIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0000786nucleosomeIEAcellular_component
GO:0009725response to hormone stimulusIEAbiological_process


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