Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ID1_HUMAN
Description:inhibitor of DNA binding 1, dominant negative helix-loop-helix protein [Source:HGNC Symbol;Acc:5360]
Location:chr20 q11.21
Node attribute:substrate; ubiquitination(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S111QLELNsESEVGPhosphoSitePlus
S36VVRCLsEQSVAPhosphoSitePlus

Dephosphorylation site
ID1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365280D100GTCGAOvarian Cancer21720365, 18772890
ENSP00000365280D100GCOSMICOvarian Cancer21720365
ENSP00000365273*150LCOSMICHead and Neck Cancer21798893

Differential expressed protein
ID1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ID1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANID1_HUMANkinase -> substrateNetPath
MK09_HUMANID1_HUMANkinase -> substrateRobert H Newman (2013)
SMUF2_HUMANID1_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0010621negative regulation of transcription by transcriptTASbiological_process
GO:0060425lung morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043408regulation of MAPK cascadeIEAbiological_process
GO:0045765regulation of angiogenesisIEAbiological_process
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001525angiogenesisTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001886endothelial cell morphogenesisIEAbiological_process
GO:0046677response to antibioticIEAbiological_process
GO:0032963collagen metabolic processIEAbiological_process
GO:0048514blood vessel morphogenesisTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0043534blood vessel endothelial cell migrationTASbiological_process
GO:0060426lung vasculature developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0031648protein destabilizationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0043392negative regulation of DNA bindingIEAbiological_process