Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IASPP_HUMAN
Description:protein phosphatase 1, regulatory subunit 13 like [Source:HGNC Symbol;Acc:18838]
Location:chr19 q13.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T209PRPPAtAYDAPPhosphoSitePlus
S567PEPELsPITEGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S120KGRPSsPRTPLPhosphoSitePlus; HPRD; phosphoELM
Y269SQTASyERLDVPhosphoSitePlus
Y259DLDVAyEKKPSPhosphoSitePlus
T241AQDDLtLRRRPPhosphoSitePlus; HPRD; SysPTM
Y109PTLHPySPLSPPhosphoSitePlus; HPRD
S292PWRESsLDGLGPhosphoSitePlus
S345GTLPRsWQPVSPhosphoSitePlus
Y543THKKQyQQIISPhosphoSitePlus
S395AMLPGsPLFTRPhosphoSitePlus; HPRD; phosphoELM
S220ASAFGsSLLGSHPRD; phosphoELM
S597APSQSsPPEQPPhosphoSitePlus; HPRD; phosphoELM
S158LGRAPsPRPGPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S102FGRSEsAPTLHPhosphoSitePlus; HPRD; phosphoELM
S594PPPAPsQSSPPHPRD; phosphoELM
S187GSPRGsPLAEGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S320VSPLAsDRRSDPhosphoSitePlus
S152DGAGSsLGRAPHPRD; SysPTM
S282RPASPsLQLLPPhosphoSitePlus
S291LPWREsSLDGLPhosphoSitePlus
Y211PPATAyDAPASPhosphoSitePlus; HPRD; phosphoELM
S119PKGRPsSPRTPPhosphoSitePlus; HPRD; phosphoELM
S203PERGPsPRPPAPhosphoSitePlus; HPRD; phosphoELM
S134PDAYGsLDRATPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S357IPMPPsSPQPRPhosphoSitePlus; HPRD; phosphoELM
T308NLTSAtLPRNYPhosphoSitePlus
S358PMPPSsPQPRGPhosphoSitePlus; HPRD; phosphoELM
T90PRKAAtDGADTPhosphoSitePlus
S113PYSPLsPKGRPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S268PSQTAsYERLDPhosphoSitePlus
S53SLWSDsPAPPGHPRD
S332GSYRRsLGSAGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S280FARPAsPSLQLPhosphoSitePlus; HPRD; phosphoELM
Y126PRTPLyLQPDAPhosphoSitePlus
T341AGPSGtLPRSWPhosphoSitePlus; HPRD; SysPTM
S110TLHPYsPLSPKPhosphoSitePlus; HPRD; phosphoELM
S526LKRRGsMEQAPPhosphoSitePlus; HPRD; phosphoELM
S183LGRAGsPRGSPPhosphoSitePlus; HPRD; phosphoELM
S81PEPFGsRGSPRPhosphoSitePlus; HPRD; phosphoELM
S225SSLLGsGGSAFPhosphoSitePlus; HPRD; phosphoELM
T123PSSPRtPLYLQPhosphoSitePlus; HPRD; phosphoELM
T173QQGPPtPFDFLPhosphoSitePlus
Y70SRPPRySSSSIPhosphoSitePlus
Y132LQPDAyGSLDRPhosphoSitePlus; HPRD; phosphoELM
S84FGSRGsPRKAAPhosphoSitePlus; HPRD
S616LRKAGsPRKARPhosphoSitePlus
S316RNYKVsPLASDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S74R.YSSSSIPEPFGSRGSPR.KSysPTM 2.0

Dephosphorylation site
IASPP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354218Y814HCOSMICHead and Neck Cancer21984974

Differential expressed protein
IASPP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IASPP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1D_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
STK40_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
STK38_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CLK3_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
UHMK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TOPK_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IASPP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042633hair cycleIEAbiological_process
GO:0031076embryonic camera-type eye developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0035264multicellular organism growthIEAbiological_process
GO:0008134transcription factor bindingTASmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0060048cardiac muscle contractionIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003215cardiac right ventricle morphogenesisIEAbiological_process
GO:0048871multicellular organismal homeostasisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003714transcription corepressor activityTASmolecular_function
GO:0003229ventricular cardiac muscle tissue developmentIEAbiological_process