| UniProt/SwissProt ID: | AAKG3_HUMAN |
| Description: | protein kinase, AMP-activated, gamma 3 non-catalytic subunit [Source:HGNC Symbol;Acc:9387] |
| Location: | chr2 q35 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T323 | VLHILtHKRLL | CBS | PhosphoSitePlus |
| S336 | LHIFGsLLPRP | PhosphoSitePlus | |
| Dephosphorylation site |
| AAKG3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000436068 | L331V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000436068 | R252C | COSMIC | Lung Cancer | 20668451 | ENSP00000233944 | R252C | COSMIC | Lung Cancer | 20668451 | ENSP00000233944 | L331V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| AAKG3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AAKG3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RAF1_HUMAN | AAKG3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| AAKG3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005978 | glycogen biosynthetic process | IEA | biological_process |
| GO:0007243 | intracellular protein kinase cascade | TAS | biological_process |
| GO:0046320 | regulation of fatty acid oxidation | TAS | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0031588 | AMP-activated protein kinase complex | IEA | cellular_component |
| GO:0006633 | fatty acid biosynthetic process | IEA | biological_process |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0015758 | glucose transport | IEA | biological_process |
| GO:0004679 | AMP-activated protein kinase activity | TAS | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007050 | cell cycle arrest | TAS | biological_process |
| GO:0019901 | protein kinase binding | IDA | molecular_function |