| UniProt/SwissProt ID: | RRAS2_HUMAN |
| Description: | related RAS viral (r-ras) oncogene homolog 2 [Source:HGNC Symbol;Acc:17271] |
| Location: | chr11 p15.2 |
| Node attribute: | PPI(source); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S10 | GWRDGsGQEKY | PhosphoSitePlus | |
| Y43 | YFVTDyDPTIE | Ras | PhosphoSitePlus |
| T190 | PSPEPtRKEKD | PhosphoSitePlus; SysPTM | |
| S186 | QECPPsPEPTR | PhosphoSitePlus; phosphoELM; SysPTM | |
| Dephosphorylation site |
| RRAS2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256196 | G24D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000256196 | Q72L | HPI | Ovarian Cancer | 8052619 |
| Differential expressed protein |
| RRAS2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RRAS2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | RRAS2_HUMAN | kinase -> substrate | KEGG |
| RASA2_HUMAN | RRAS2_HUMAN | other | KEGG |
| RRAS2_HUMAN | ARAF_HUMAN | other | KEGG |
| RRAS2_HUMAN | ARHG6_HUMAN | other | KEGG |
| RASA1_HUMAN | RRAS2_HUMAN | other | KEGG |
| RGRF1_HUMAN | RRAS2_HUMAN | other | KEGG |
| RRAS2_HUMAN | RAF1_HUMAN | other | KEGG |
| SOS1_HUMAN | RRAS2_HUMAN | other | KEGG |
| RRAS2_HUMAN | AFAD_HUMAN | other | KEGG |
| NF1_HUMAN | RRAS2_HUMAN | other | KEGG |
| RRAS2_HUMAN | BRAF_HUMAN | other | KEGG |
| GRP1_HUMAN | RRAS2_HUMAN | other | KEGG |
| RRAS2_HUMAN | MOS_HUMAN | other | KEGG |
| RRAS2_HUMAN | PI3R5_HUMAN | other | KEGG |
| RPGF2_HUMAN | RRAS2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04530 | Tight junction |
| hsa05166 | HTLV-I infection |
| hsa04010 | MAPK signaling pathway |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0030335 | positive regulation of cell migration | IEA | biological_process |
| GO:0005783 | endoplasmic reticulum | NAS | cellular_component |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0009987 | cellular process | IEA | biological_process |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0006886 | intracellular protein transport | IEA | biological_process |