| UniProt/SwissProt ID: | IF4E_HUMAN |
| Description: | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:3287] |
| Location: | chr4 q23 |
| Node attribute: | PPI(target); substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S209 | ATKSGsTTKNR | PRKCA | HPRD |
| S209 | ATKSGsTTKNR | PRKCB | HPRD |
| S209 | ATKSGsTTKNR | MNK2 | RegPhos |
| S209 | ATKSGsTTKNR | MNK1 | RegPhos |
| S209 | ATKSGsTTKNR | PRKCG | HPRD |
| T3 | ___MAtVEPET | PhosphoSitePlus | |
| S53 | FKNDKsKTWQA | IF4E | PhosphoSitePlus |
| T210 | TKSGStTKNRF | PhosphoSitePlus | |
| T9 | VEPETtPTPNP | PhosphoSitePlus; HPRD | |
| Y183 | HIGRVyKERLG | IF4E | PhosphoSitePlus |
| T22 | TEEEKtESNQE | HPRD | |
| S209 | ATKSGsTTKNR | PKCg | RegPhos |
| S209 | ATKSGsTTKNR | PKCa | RegPhos |
| S209 | ATKSGsTTKNR | PKCb | RegPhos |
| S53 | FKNDKsKTWQA | HPRD; phosphoELM; RegPhos | |
| S209 | ATKSGsTTKNR | MKNK2 | HPRD |
| S209 | ATKSGsTTKNR | MKNK1 | HPRD |
| T17 | PNPPTtEEEKT | PhosphoSitePlus | |
| S209 | ATKSGsTTKNR | PhosphoSitePlus; phosphoELM | |
| S209 | ATKSGsTTKNR | Mnk2 | phosphoELM; RegPhos |
| S209 | ATKSGsTTKNR | Mnk1 | phosphoELM; RegPhos |
| T203 | QSHADtATKSG | PhosphoSitePlus | |
| T16 | TPNPPtTEEEK | PhosphoSitePlus | |
| S209 | ATKSGsTTKNR | PKC_group | RegPhos |
| Dephosphorylation site |
| IF4E_HUMAN do not have dephosphorylation site. |
| Mutation site |
| IF4E_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000389624 | Leukemia | Normal vs. Cancer | cell line | Up | 6.4 | 17022645 | ENSP00000389624 | Leukemia | Normal vs. Cancer | cell line | Up | 3.3 | 17022645 | ENSP00000389624 | Breast Cancer | Treatment (Antiestrogen-sensitive vs. Antiestrogen-resistant) | cell line | Down | 0.16 | 14557597 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S209 | DTATKSGsTTKNRFV | psoriasis | 19663871 | PhosphoSitePlus | S209 | DTATKSGsTTKNRFV | prostate cancer | 20679199 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCG_HUMAN | IF4E_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | IF4E_HUMAN | kinase -> substrate | RegPhos |
| KPCB_HUMAN | IF4E_HUMAN | kinase -> substrate | HPRD |
| MKNK1_HUMAN | IF4E_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| KPCA_HUMAN | IF4E_HUMAN | kinase -> substrate | HPRD |
| MKNK2_HUMAN | IF4E_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos; Robert H Newman (2013) |
| 4EBP1_HUMAN | IF4E_HUMAN | other | KEGG |
| MYC_HUMAN | IF4E_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04910 | Insulin signaling pathway |
| hsa03013 | RNA transport |
| hsa04150 | mTOR signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045931 | positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0005845 | mRNA cap binding complex | IEA | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deaden | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016281 | eukaryotic translation initiation factor 4F comple | IEA | cellular_component |
| GO:0010494 | cytoplasmic stress granule | IDA | cellular_component |
| GO:0006406 | mRNA export from nucleus | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005845 | mRNA cap binding complex | IDA | cellular_component |
| GO:0031370 | eukaryotic initiation factor 4G binding | IEA | molecular_function |
| GO:0006417 | regulation of translation | IEA | biological_process |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0000932 | cytoplasmic mRNA processing body | IDA | cellular_component |
| GO:0006412 | translation | TAS | biological_process |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030324 | lung development | IEA | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0016442 | RNA-induced silencing complex | IDA | cellular_component |
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0003743 | translation initiation factor activity | ISS | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0006413 | translational initiation | TAS | biological_process |
| GO:0000339 | RNA cap binding | TAS | molecular_function |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0003743 | translation initiation factor activity | IEA | molecular_function |
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |