| UniProt/SwissProt ID: | ZHX2_HUMAN |
| Description: | zinc fingers and homeoboxes 2 [Source:HGNC Symbol;Acc:18513] |
| Location: | chr8 q24.13 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T566 | RLRVEtKLSRR | Homeobox | PhosphoSitePlus |
| T411 | KRPLVtPQAAP | PhosphoSitePlus | |
| T37 | EKGIGtPQPDV | HPRD | |
| T222 | RLVTDtAEILS | PhosphoSitePlus | |
| Y470 | DDAEVyRLIEV | ADPrib_exo_Tox; Homeobox | PhosphoSitePlus |
| S775 | DRSEGsSRDGQ | PhosphoSitePlus | |
| Y267 | LNTTKyNSALD | PhosphoSitePlus | |
| T713 | VARKAtKPMAE | PhosphoSitePlus | |
| T220 | TARLVtDTAEI | PhosphoSitePlus | |
| Y705 | ADDHGyDAVAR | PhosphoSitePlus | |
| S569 | VETKLsRREID | Homeobox | PhosphoSitePlus |
| T344 | QSVPPtITVLP | PhosphoSitePlus; HPRD | |
| S719 | KPMAEsPKNGG | PhosphoSitePlus | |
| S442 | PLTPAsDRKKT | PhosphoSitePlus | |
| S586 | RKLRDsMEQAV | PhosphoSitePlus | |
| S7 | ASKRKsTTPCM | PhosphoSitePlus | |
| T439 | ANPPLtPASDR | PhosphoSitePlus | |
| T8 | SKRKStTPCMV | PhosphoSitePlus | |
| T207 | KPEEItPENHV | PhosphoSitePlus | |
| T9 | KRKSTtPCMVR | PhosphoSitePlus | |
| T215 | NHVEGtARLVT | PhosphoSitePlus | |
| T355 | AQLAPtKVTQP | PhosphoSitePlus; HPRD | |
| S776 | RSEGSsRDGQG | PhosphoSitePlus | |
| S269 | TTKYNsALDTN | PhosphoSitePlus | |
| Dephosphorylation site |
| ZHX2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000314709 | N116K | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000314709 | G779S | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000314709 | G601A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000314709 | S54F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ZHX2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZHX2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZHX2_HUMAN | MP2K1_HUMAN | kinase -> substrate | RegPhos |
| ZHX2_HUMAN | MYC_HUMAN | kinase -> substrate | RegPhos |
| ZHX2_HUMAN | MP2K2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| ZHX2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0035019 | somatic stem cell maintenance | IEA | biological_process |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045665 | negative regulation of neuron differentiation | IEA | biological_process |
| GO:0046982 | protein heterodimerization activity | IDA | molecular_function |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |
| GO:0006402 | mRNA catabolic process | IEA | biological_process |