| UniProt/SwissProt ID: | CTCF_HUMAN |
| Description: | CCCTC-binding factor (zinc finger protein) [Source:HGNC Symbol;Acc:13723] |
| Location: | chr16 q22.1 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T516 | IMHKRtHTGEK | zf-C2H2 | PhosphoSitePlus |
| S382 | RPFQCsLCSYA | zf-C2H2 | PhosphoSitePlus |
| T400 | KRHMRtHSGEK | zf-C2H2 | PhosphoSitePlus |
| S450 | VIARKsDLGVH | zf-C2H2 | PhosphoSitePlus |
| T317 | HLNTHtGTRPH | PhosphoSitePlus; HPRD | |
| S450 | VIARKsDLGVH | HPRD | |
| Y410 | KPYECyICHAR | HPRD | |
| S612 | EDSSDsENAEP | PhosphoSitePlus; HPRD; phosphoELM | |
| T709 | AQPAAtDAPNG | PhosphoSitePlus | |
| Y197 | QKDPDyQPPAK | PhosphoSitePlus | |
| S610 | KKEDSsDSENA | PhosphoSitePlus; HPRD; phosphoELM | |
| S723 | PEMILsMMDR_ | PhosphoSitePlus | |
| S402 | HMRTHsGEKPY | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T289 | HMKSHtDERPH | PhosphoSitePlus; HPRD | |
| T305 | GRAFRtVTLLR | zf-C2H2 | PhosphoSitePlus |
| T518 | HKRTHtGEKPY | PhosphoSitePlus | |
| S609 | SKKEDsSDSEN | PhosphoSitePlus; HPRD; phosphoELM | |
| T307 | AFRTVtLLRNH | zf-C2H2 | PhosphoSitePlus |
| S604 | KRKMRsKKEDS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y410 | KPYECyICHAR | zf-C2H2 | PhosphoSitePlus |
| T333 | DMAFVtSGELV | HPRD | |
| Y343 | VRHRRyKHTHE | HPRD | |
| T400 | KRHMRtHSGEK | HPRD | |
| Y407 | SGEKPyECYIC | HPRD | |
| Y545 | MHFKRyHDPNF | zf-C2H2 | PhosphoSitePlus |
| T319 | NTHTGtRPHKC | PhosphoSitePlus | |
| T642 | EPQPVtPAPPP | PhosphoSitePlus | |
| S558 | AAFVCsKCGKT | zf-C2H2 | PhosphoSitePlus |
| T431 | ILQKHtENVAK | PhosphoSitePlus; HPRD | |
| S526 | KPYACsHCDKT | zf-C2H2 | PhosphoSitePlus |
| T346 | RRYKHtHEKPF | PhosphoSitePlus; HPRD | |
| T717 | PNGDLtPEMIL | PhosphoSitePlus; HPRD | |
| T374 | HIRSHtGERPF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| CTCF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264010 | G466S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264010 | R339W | HPI | Renal Cancer | 11782357 | ENSP00000264010 | E291D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264010 | M1I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000264010 | H345R | HPI | Prostate Cancer | 11782357 | ENSP00000264010 | K344E | HPI | Breast Cancer | 11782357 | ENSP00000264010 | R448Q | HPI | Renal Cancer | 11782357 | ENSP00000264010 | R457* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CTCF_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CTCF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CTCF_HUMAN | MYC_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CTCF_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0006349 | regulation of gene expression by genetic imprintin | IEA | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0031060 | regulation of histone methylation | IEA | biological_process |
| GO:0006306 | DNA methylation | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0016584 | nucleosome positioning | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010629 | negative regulation of gene expression | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0040029 | regulation of gene expression, epigenetic | IMP | biological_process |
| GO:0010628 | positive regulation of gene expression | IMP | biological_process |
| GO:0000775 | chromosome, centromeric region | IDA | cellular_component |
| GO:0043035 | chromatin insulator sequence binding | IDA | molecular_function |
| GO:0007059 | chromosome segregation | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0035065 | regulation of histone acetylation | IEA | biological_process |
| GO:0000793 | condensed chromosome | IDA | cellular_component |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0010628 | positive regulation of gene expression | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003714 | transcription corepressor activity | TAS | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IDA | molecular_function |
| GO:0070602 | regulation of centromeric sister chromatid cohesio | NAS | biological_process |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0010216 | maintenance of DNA methylation | IEA | biological_process |
| GO:0040030 | regulation of molecular function, epigenetic | IMP | biological_process |
| GO:0008270 | zinc ion binding | TAS | molecular_function |