Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CTCF_HUMAN
Description:CCCTC-binding factor (zinc finger protein) [Source:HGNC Symbol;Acc:13723]
Location:chr16 q22.1
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T516IMHKRtHTGEKzf-C2H2PhosphoSitePlus
S382RPFQCsLCSYAzf-C2H2PhosphoSitePlus
T400KRHMRtHSGEKzf-C2H2PhosphoSitePlus
S450VIARKsDLGVHzf-C2H2PhosphoSitePlus
T317HLNTHtGTRPHPhosphoSitePlus; HPRD
S450VIARKsDLGVHHPRD
Y410KPYECyICHARHPRD
S612EDSSDsENAEPPhosphoSitePlus; HPRD; phosphoELM
T709AQPAAtDAPNGPhosphoSitePlus
Y197QKDPDyQPPAKPhosphoSitePlus
S610KKEDSsDSENAPhosphoSitePlus; HPRD; phosphoELM
S723PEMILsMMDR_PhosphoSitePlus
S402HMRTHsGEKPYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T289HMKSHtDERPHPhosphoSitePlus; HPRD
T305GRAFRtVTLLRzf-C2H2PhosphoSitePlus
T518HKRTHtGEKPYPhosphoSitePlus
S609SKKEDsSDSENPhosphoSitePlus; HPRD; phosphoELM
T307AFRTVtLLRNHzf-C2H2PhosphoSitePlus
S604KRKMRsKKEDSPhosphoSitePlus; HPRD; phosphoELM
Y410KPYECyICHARzf-C2H2PhosphoSitePlus
T333DMAFVtSGELVHPRD
Y343VRHRRyKHTHEHPRD
T400KRHMRtHSGEKHPRD
Y407SGEKPyECYICHPRD
Y545MHFKRyHDPNFzf-C2H2PhosphoSitePlus
T319NTHTGtRPHKCPhosphoSitePlus
T642EPQPVtPAPPPPhosphoSitePlus
S558AAFVCsKCGKTzf-C2H2PhosphoSitePlus
T431ILQKHtENVAKPhosphoSitePlus; HPRD
S526KPYACsHCDKTzf-C2H2PhosphoSitePlus
T346RRYKHtHEKPFPhosphoSitePlus; HPRD
T717PNGDLtPEMILPhosphoSitePlus; HPRD
T374HIRSHtGERPFPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
CTCF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264010G466SCOSMICHead and Neck Cancer21798893
ENSP00000264010R339WHPIRenal Cancer11782357
ENSP00000264010E291DCOSMICOvarian Cancer21720365
ENSP00000264010M1IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000264010H345RHPIProstate Cancer11782357
ENSP00000264010K344EHPIBreast Cancer11782357
ENSP00000264010R448QHPIRenal Cancer11782357
ENSP00000264010R457*COSMICSkin Cancer21984974

Differential expressed protein
CTCF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CTCF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CTCF_HUMANMYC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CTCF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005622intracellularIEAcellular_component
GO:0006349regulation of gene expression by genetic imprintinIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0031060regulation of histone methylationIEAbiological_process
GO:0006306DNA methylationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0016584nucleosome positioningIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0040029regulation of gene expression, epigeneticIMPbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0000775chromosome, centromeric regionIDAcellular_component
GO:0043035chromatin insulator sequence bindingIDAmolecular_function
GO:0007059chromosome segregationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0035065regulation of histone acetylationIEAbiological_process
GO:0000793condensed chromosomeIDAcellular_component
GO:0016568chromatin modificationIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0070602regulation of centromeric sister chromatid cohesioNASbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0005654nucleoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0010216maintenance of DNA methylationIEAbiological_process
GO:0040030regulation of molecular function, epigeneticIMPbiological_process
GO:0008270zinc ion bindingTASmolecular_function


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