| UniProt/SwissProt ID: | YBOX1_HUMAN |
| Description: | Y box binding protein 1 [Source:HGNC Symbol;Acc:8014] |
| Location: | chr1 p34.2 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S174 | EKNEGsESAPE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S102 | RKYLRsVGDGE | AKT1 | HPRD; RegPhos |
| S3 | ___MSsEAETQ | PhosphoSitePlus | |
| S102 | RKYLRsVGDGE | phosphoELM; RegPhos | |
| Y208 | GRRPQySNPPV | PhosphoSitePlus | |
| Y196 | RRFPPyYMRRP | PhosphoSitePlus | |
| S102 | RKYLRsVGDGE | CSD | PhosphoSitePlus |
| S176 | NEGSEsAPEGQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S167 | YQNSEsGEKNE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T108 | VGDGEtVEFDV | CSD | PhosphoSitePlus |
| Y99 | NNPRKyLRSVG | CSD | PhosphoSitePlus |
| Y162 | NYQQNyQNSES | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S209 | RRPQYsNPPVQ | PhosphoSitePlus | |
| S2 | EAET | HPRD; SysPTM | |
| T80 | INRNDtKEDVF | CSD | PhosphoSitePlus |
| Y287 | RRNFNyRRRRP | PhosphoSitePlus | |
| Y145 | ADRNHyRRYPR | PhosphoSitePlus | |
| S102 | RKYLRsVGDGE | AKT1(PKB | RegPhos |
| S313 | PPAENsSAPEA | PhosphoSitePlus; HPRD | |
| S165 | QNYQNsESGEK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S2 | ____MsSEAET | PhosphoSitePlus; SysPTM | |
| T271 | NQGDEtQGQQP | PhosphoSitePlus | |
| Y197 | RFPPYyMRRPY | PhosphoSitePlus | |
| T7 | QPPA | HPRD | |
| S314 | PAENSsAPEAE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y72 | NVRNGyGFINR | CSD | PhosphoSitePlus |
| Y158 | GPPRNyQQNYQ | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| YBOX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361626 | D222H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361626 | G71V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361626 | D307N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000361626 | G71V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361626 | P149R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361626 | Q160K | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000361626 | D222H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361626 | P149R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361626 | Melanoma | Treatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed) | cell line | Up | 2.3 | 17854218 | ENSP00000361626 | Non-small cell lung carcinoma | Normal vs. Cancer | cell line | Up | 15359725 | ENSP00000361626 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.3 | 20804217 | ENSP00000361626 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.31 | 19610612 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S102 | CSD | NPRKYLRsVGDGETV | breast cancer | 19036157 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | YBOX1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | YBOX1_HUMAN | kinase -> substrate | RegPhos |
| MYC_HUMAN | YBOX1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| YBOX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071204 | histone pre-mRNA 3'end processing complex | IEA | cellular_component |
| GO:0005689 | U12-type spliceosomal complex | IDA | cellular_component |
| GO:0051154 | negative regulation of striated muscle cell differ | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0070934 | CRD-mediated mRNA stabilization | IMP | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0070937 | CRD-mediated mRNA stability complex | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0003690 | double-stranded DNA binding | TAS | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0003697 | single-stranded DNA binding | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IDA | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0010494 | cytoplasmic stress granule | IDA | cellular_component |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0071204 | histone pre-mRNA 3'end processing complex | ISS | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0051781 | positive regulation of cell division | IEA | biological_process |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |