Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:YBOX1_HUMAN
Description:Y box binding protein 1 [Source:HGNC Symbol;Acc:8014]
Location:chr1 p34.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S174EKNEGsESAPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S102RKYLRsVGDGEAKT1HPRD; RegPhos
S3___MSsEAETQPhosphoSitePlus
S102RKYLRsVGDGEphosphoELM; RegPhos
Y208GRRPQySNPPVPhosphoSitePlus
Y196RRFPPyYMRRPPhosphoSitePlus
S102RKYLRsVGDGECSDPhosphoSitePlus
S176NEGSEsAPEGQPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S167YQNSEsGEKNEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T108VGDGEtVEFDVCSDPhosphoSitePlus
Y99NNPRKyLRSVGCSDPhosphoSitePlus
Y162NYQQNyQNSESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S209RRPQYsNPPVQPhosphoSitePlus
S2EAETHPRD; SysPTM
T80INRNDtKEDVFCSDPhosphoSitePlus
Y287RRNFNyRRRRPPhosphoSitePlus
Y145ADRNHyRRYPRPhosphoSitePlus
S102RKYLRsVGDGEAKT1(PKBRegPhos
S313PPAENsSAPEAPhosphoSitePlus; HPRD
S165QNYQNsESGEKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S2____MsSEAETPhosphoSitePlus; SysPTM
T271NQGDEtQGQQPPhosphoSitePlus
Y197RFPPYyMRRPYPhosphoSitePlus
T7QPPAHPRD
S314PAENSsAPEAEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y72NVRNGyGFINRCSDPhosphoSitePlus
Y158GPPRNyQQNYQPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
YBOX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361626D222HTCGAOvarian Cancer21720365, 18772890
ENSP00000361626G71VTCGAOvarian Cancer21720365, 18772890
ENSP00000361626D307NCOSMICHead and Neck Cancer21798893
ENSP00000361626G71VCOSMICOvarian Cancer21720365
ENSP00000361626P149RTCGAOvarian Cancer21720365, 18772890
ENSP00000361626Q160KCOSMICHead and Neck Cancer21798897
ENSP00000361626D222HCOSMICOvarian Cancer21720365
ENSP00000361626P149RCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361626MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineUp2.317854218
ENSP00000361626Non-small cell lung carcinomaNormal vs. Cancercell lineUp15359725
ENSP00000361626Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.320804217
ENSP00000361626Renal CancerNormal vs. CancertissueDown0.3119610612

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S102CSDNPRKYLRsVGDGETVbreast cancer19036157PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANYBOX1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANYBOX1_HUMANkinase -> substrateRegPhos
MYC_HUMANYBOX1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
YBOX1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071204histone pre-mRNA 3'end processing complexIEAcellular_component
GO:0005689U12-type spliceosomal complexIDAcellular_component
GO:0051154negative regulation of striated muscle cell differIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0070934CRD-mediated mRNA stabilizationIMPbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0070937CRD-mediated mRNA stability complexIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0003690double-stranded DNA bindingTASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenNASbiological_process
GO:0003697single-stranded DNA bindingIEAmolecular_function
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0003677DNA bindingIDAmolecular_function
GO:0010494cytoplasmic stress granuleIDAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0071204histone pre-mRNA 3'end processing complexISScellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0005634nucleusNAScellular_component
GO:0003723RNA bindingNASmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0005515protein bindingIPImolecular_function


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