Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	AP2A_HUMAN
Description:	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) [Source:HGNC Symbol;Acc:11742]
Location:	chr6 p24.3
Node attribute:	gene; TF

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S222	RLSLLsSTSKY		HPRD
S219	VPGRLsLLSST	TF_AP-2	PhosphoSitePlus
T218	SLLSStSKYKV		HPRD
S233	VQRRLsPPECL		HPRD
S225	LLSSTsKYKVT		HPRD; phosphoELM
S429	NNAKSsDKEEK		PhosphoSitePlus
S239	VQRRLsPPECL	TF_AP-2	PhosphoSitePlus
S219	LLSSTsKYKVT		HPRD
S223	LSLLSsTSKYK		HPRD
S326	LNRQHsDPNEQ	TF_AP-2	PhosphoSitePlus
S428	DNNAKsSDKEE		PhosphoSitePlus
S217	LSLLSsTSKYK		HPRD
S179	VSLSKsNSNAV		HPRD
Y73	QSQDPySHVND		PhosphoSitePlus
S187	LSKSNsNAVSA		PhosphoSitePlus; HPRD; phosphoELM
S181	LSKSNsNAVSA		HPRD
S239	VQRRLsPPECL		HPRD; phosphoELM
S225	LLSSTsKYKVT	TF_AP-2	PhosphoSitePlus
T224	SLLSStSKYKV		HPRD
S185	VSLSKsNSNAV		PhosphoSitePlus; HPRD; phosphoELM
S216	RLSLLsSTSKY		HPRD
S258	LRRAKsKNGGR	TF_AP-2	PhosphoSitePlus

Dephosphorylation site

AP2A_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000368924	I9F	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000368928	P66R	COSMIC	Ovarian Cancer	20826764
ENSP00000418541	I9F	BIOMART	Breast Cancer	21930507, 21930502

Differential expressed protein

AP2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site

AP2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
AP2A_HUMAN	IFNG_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	ATF2_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	APOB_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	MT2_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	TVA2_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	GFAP_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	ADML_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	DCOR_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	K1C14_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	CO3_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	DHB1_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	CEAM1_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	MMP2_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	HSPB1_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	MLTK_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	MIP_HUMAN	TF -> target gene	TRANSFAC
ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	CCNB1_HUMAN	TF -> target gene	TRANSFAC
KLF12_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	KIT_HUMAN	TF -> target gene	TRANSFAC
AP2A_HUMAN	SOMA_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

AP2A_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0048730	epidermis morphogenesis	IEA	biological_process
GO:0000979	RNA polymerase II core promoter sequence-specific	IDA	molecular_function
GO:0021559	trigeminal nerve development	IEA	biological_process
GO:0060325	face morphogenesis	IEA	biological_process
GO:0001105	RNA polymerase II transcription coactivator activi	IEA	molecular_function
GO:0061029	eyelid development in camera-type eye	IEA	biological_process
GO:0010944	negative regulation of transcription by competitiv	IMP	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0043525	positive regulation of neuron apoptotic process	IDA	biological_process
GO:0060349	bone morphogenesis	IEA	biological_process
GO:0001843	neural tube closure	IEA	biological_process
GO:0030335	positive regulation of cell migration	IEA	biological_process
GO:0021623	oculomotor nerve formation	IEA	biological_process
GO:0043066	negative regulation of apoptotic process	IDA	biological_process
GO:0003713	transcription coactivator activity	IDA	molecular_function
GO:0000976	transcription regulatory region sequence-specific	IDA	molecular_function
GO:0001077	RNA polymerase II core promoter proximal region se	IEA	molecular_function
GO:0003409	optic cup structural organization	IEA	biological_process
GO:0045892	negative regulation of transcription, DNA-dependen	IDA	biological_process
GO:0042059	negative regulation of epidermal growth factor rec	IEA	biological_process
GO:0021623	oculomotor nerve formation	ISS	biological_process
GO:0010628	positive regulation of gene expression	ISS	biological_process
GO:0021884	forebrain neuron development	IEA	biological_process
GO:0000981	sequence-specific DNA binding RNA polymerase II tr	IDA	molecular_function
GO:0048701	embryonic cranial skeleton morphogenesis	ISS	biological_process
GO:0072210	metanephric nephron development	IEA	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0048596	embryonic camera-type eye morphogenesis	IEA	biological_process
GO:0001106	RNA polymerase II transcription corepressor activi	IEA	molecular_function
GO:0010842	retina layer formation	IEP	biological_process
GO:0030501	positive regulation of bone mineralization	IDA	biological_process
GO:0070172	positive regulation of tooth mineralization	IDA	biological_process
GO:0035115	embryonic forelimb morphogenesis	IEA	biological_process
GO:0002089	lens morphogenesis in camera-type eye	IEA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IDA	biological_process
GO:0001078	RNA polymerase II core promoter proximal region se	IDA	molecular_function
GO:0048705	skeletal system morphogenesis	IEA	biological_process
GO:0061303	cornea development in camera-type eye	IEA	biological_process
GO:0008285	negative regulation of cell proliferation	IEA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	ISS	biological_process
GO:0003682	chromatin binding	IEA	molecular_function
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular_component
GO:0045595	regulation of cell differentiation	IDA	biological_process
GO:0007399	nervous system development	IEA	biological_process
GO:0048701	embryonic cranial skeleton morphogenesis	IEA	biological_process
GO:0007605	sensory perception of sound	IMP	biological_process
GO:0010172	embryonic body morphogenesis	IEA	biological_process
GO:0042472	inner ear morphogenesis	IMP	biological_process
GO:0035115	embryonic forelimb morphogenesis	ISS	biological_process
GO:0046983	protein dimerization activity	IDA	molecular_function
GO:0060235	lens induction in camera-type eye	IEA	biological_process
GO:0005794	Golgi apparatus	IDA	cellular_component
GO:0003682	chromatin binding	ISS	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0048485	sympathetic nervous system development	IEA	biological_process
GO:2000378	negative regulation of reactive oxygen species met	IDA	biological_process
GO:0000122	negative regulation of transcription from RNA poly	IDA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0000978	RNA polymerase II core promoter proximal region se	IDA	molecular_function
GO:0045664	regulation of neuron differentiation	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0009880	embryonic pattern specification	IEA	biological_process
GO:0021559	trigeminal nerve development	ISS	biological_process
GO:0003404	optic vesicle morphogenesis	ISS	biological_process
GO:0060349	bone morphogenesis	ISS	biological_process
GO:0008285	negative regulation of cell proliferation	IDA	biological_process
GO:0043588	skin development	IEA	biological_process
GO:0071281	cellular response to iron ion	IDA	biological_process
GO:0071711	basement membrane organization	IEA	biological_process
GO:0035136	forelimb morphogenesis	IEA	biological_process
GO:0006355	regulation of transcription, DNA-dependent	IEA	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	IEA	molecular_function
GO:0003151	outflow tract morphogenesis	IEA	biological_process
GO:0003334	keratinocyte development	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0043565	sequence-specific DNA binding	IDA	molecular_function
GO:0061029	eyelid development in camera-type eye	ISS	biological_process
GO:0003409	optic cup structural organization	ISS	biological_process
GO:0005813	centrosome	IDA	cellular_component
GO:0003404	optic vesicle morphogenesis	IEA	biological_process
GO:0000987	core promoter proximal region sequence-specific DN	IEA	molecular_function
GO:0007423	sensory organ development	IEA	biological_process
GO:0060021	palate development	IMP	biological_process
GO:0006357	regulation of transcription from RNA polymerase II	IEA	biological_process
GO:0014032	neural crest cell development	IEA	biological_process
GO:0006366	transcription from RNA polymerase II promoter	IDA	biological_process
GO:0001822	kidney development	IMP	biological_process
GO:0000987	core promoter proximal region sequence-specific DN	IDA	molecular_function
GO:0001077	RNA polymerase II core promoter proximal region se	IDA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0000979	RNA polymerase II core promoter sequence-specific	IEA	molecular_function
GO:0000980	RNA polymerase II distal enhancer sequence-specifi	IEA	molecular_function
GO:0042803	protein homodimerization activity	TAS	molecular_function
GO:0000982	RNA polymerase II core promoter proximal region se	IDA	molecular_function
GO:0021506	anterior neuropore closure	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network