Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDX18_HUMAN
Description:DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Source:HGNC Symbol;Acc:2741]
Location:chr2 q14.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T360PTRRQtMLFSADEADPhosphoSitePlus
T68VGLSEtQNGGMGAGA_bind; CDC27PhosphoSitePlus
Y442SVKYHyELLNYPhosphoSitePlus
S74QNGGMsQEAVGGAGA_bind; CDC27PhosphoSitePlus
S86IKVTKsPQKSTHPRD
S227AAKTGsGKTLADEADPhosphoSitePlus
Y440CMSVKyHYELLPhosphoSitePlus
S2LPMKHPRD
T225LAAAKtGSGKTHPRD
T368FSATQtRKVEDDEADPhosphoSitePlus
S227AAKTGsGKTLAHPRD
S2____MsHLPMKPhosphoSitePlus
T225LAAAKtGSGKTDEADPhosphoSitePlus
S36SNLTLsETQNGGAGA_bind; CDC27PhosphoSitePlus
T368FSATQtRKVEDHPRD
S86IKVTKsPQKSTGAGA_bind; CDC27PhosphoSitePlus
Y385KKEPLyVGVDDPhosphoSitePlus
S74QNGGMsQEAVGHPRD
Y447YELLNyIDLPVHelicase_CPhosphoSitePlus
T230TGSGKtLAFLIDEADPhosphoSitePlus

Dephosphorylation site
DDX18_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263239L568SCOSMICOvarian Cancer21720365
ENSP00000263239G41RSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000263239E550KCOSMICLung Cancer
ENSP00000263239L568STCGAOvarian Cancer21720365, 18772890
ENSP00000263239K660NCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263239Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.318646787
ENSP00000263239Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
DDX18_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MYC_HUMANDDX18_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
DDX18_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0004004ATP-dependent RNA helicase activityTASmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0004386helicase activityIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


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