Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDN2B_HUMAN
Description:cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [Source:HGNC Symbol;Acc:1788]
Location:chr9 p21.3
Node attribute:PPI(target); gene

Phosphorylation site
CDN2B_HUMAN do not have phosphorylation site.

Dephosphorylation site
CDN2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000276925A50VHPILung Cancer7882351
ENSP00000276925R60CDing2008, COSMICLung Cancer18948947
ENSP00000276925G47EHPILung Cancer7882351

Differential expressed protein
CDN2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDN2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MYC_HUMANCDN2B_HUMANotherKEGG
ZBT17_HUMANCDN2B_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
hsa05203Viral carcinogenesis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000086G2/M transition of mitotic cell cycleIMPbiological_process
GO:0030511positive regulation of transforming growth factor IMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042326negative regulation of phosphorylationIDAbiological_process
GO:0030219megakaryocyte differentiationIEPbiological_process
GO:0004861cyclin-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIMPbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0031575mitotic cell cycle G1/S transition checkpointIMPbiological_process
GO:0031670cellular response to nutrientIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0045944positive regulation of transcription from RNA polyTASbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0007050cell cycle arrestIMPbiological_process
GO:0031668cellular response to extracellular stimulusIMPbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiIDAbiological_process
GO:0030858positive regulation of epithelial cell differentiaIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process


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