| UniProt/SwissProt ID: | USF1_HUMAN |
| Description: | upstream transcription factor 1 [Source:HGNC Symbol;Acc:12593] |
| Location: | chr1 q23.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T153 | LLGQAtPPGTG | PhosphoSitePlus | |
| S223 | WIVQLsKIIPD | HPRD | |
| S262 | SNHRLsEELQG | PhosphoSitePlus | |
| S186 | RTHPYsPKSEA | PhosphoSitePlus | |
| Dephosphorylation site |
| USF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356999 | P192A | COSMIC | Skin Cancer | 21984974 | ENSP00000356999 | V50I | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000356999 | S145L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356999 | V22M | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| USF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| USF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| USF1_HUMAN | CP3A4_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | HXB4_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | APOC3_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | PIGR_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | MPRI_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | MYC_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | CEAM1_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | A4_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | SOX3_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | CEBPA_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | CCNB1_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | CEAM6_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | HAP1_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | TYRO_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | CATD_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | HMOX1_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | GLI1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| USF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045990 | carbon catabolite regulation of transcription | TAS | biological_process |
| GO:0042826 | histone deacetylase binding | IPI | molecular_function |
| GO:0003690 | double-stranded DNA binding | IEA | molecular_function |
| GO:0009411 | response to UV | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0019086 | late viral mRNA transcription | IDA | biological_process |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | IMP | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0000432 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0051918 | negative regulation of fibrinolysis | IC | biological_process |
| GO:0055088 | lipid homeostasis | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0042593 | glucose homeostasis | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0043425 | bHLH transcription factor binding | IPI | molecular_function |
| GO:0001666 | response to hypoxia | IMP | biological_process |
| GO:0032869 | cellular response to insulin stimulus | IDA | biological_process |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006006 | glucose metabolic process | IEA | biological_process |
| GO:0000430 | regulation of transcription from RNA polymerase II | IC | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005667 | transcription factor complex | IDA | cellular_component |