| UniProt/SwissProt ID: | NDKB_HUMAN |
| Description: | NME/NM23 nucleoside diphosphate kinase 2 [Source:HGNC Symbol;Acc:7850] |
| Location: | chr17 q21.33 |
| Node attribute: | substrate; kinase; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T94 | VMLGEtNPADS | phosphoELM | |
| S237 | IHGSDsVKSAE | HPRD | |
| H118 | GRNIIhGSDSV | NME2 | HPRD |
| S99 | TNPADsKPGTI | NDK | PhosphoSitePlus |
| Y142 | EELVDyKSCAH | PhosphoSitePlus | |
| S44 | KFLRAsEEHLK | NDK | PhosphoSitePlus |
| Y151 | AHDWVyE____ | PhosphoSitePlus | |
| S120 | NIIHGsDSVKS | HPRD | |
| H233 | GRNIIhGSDSV | NME2 | HPRD |
| S44 | KFLRAsEEHLK | phosphoELM | |
| S120 | NIIHGsDSVKS | NDK | PhosphoSitePlus |
| S131 | AEKEIsLWFKP | NDK | PhosphoSitePlus |
| S122 | IHGSDsVKSAE | NDK | PhosphoSitePlus |
| T94 | VMLGEtNPADS | NDK | PhosphoSitePlus |
| Y52 | HLKQHyIDLKD | NDK | PhosphoSitePlus |
| S159 | KFLRAsEEHLK | NME2 | HPRD |
| S44 | KFLRAsEEHLK | NME2 | HPRD |
| H118 | GRNIIhGSDSV | NDK | PhosphoSitePlus |
| S235 | NIIHGsDSVKS | HPRD | |
| S122 | IHGSDsVKSAE | HPRD | |
| Dephosphorylation site |
| NDKB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| NDKB_HUMAN do not have mutation site. |
| Differential expressed protein |
| NDKB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NDKB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NDKB_HUMAN | NDKB_HUMAN | kinase -> substrate | HPRD |
| NDKB_HUMAN | MYC_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa00230 | Purine metabolism |
| hsa01100 | Metabolic pathways |
| hsa00240 | Pyrimidine metabolism |
| hsa00230 | Purine metabolism |
| hsa00240 | Pyrimidine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006228 | UTP biosynthetic process | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0009142 | nucleoside triphosphate biosynthetic process | IDA | biological_process |
| GO:0006241 | CTP biosynthetic process | IEA | biological_process |
| GO:0006183 | GTP biosynthetic process | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0004550 | nucleoside diphosphate kinase activity | IEA | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0030027 | lamellipodium | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004673 | protein histidine kinase activity | IEA | molecular_function |
| GO:0045682 | regulation of epidermis development | IMP | biological_process |
| GO:0015949 | nucleobase-containing small molecule interconversi | TAS | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IMP | biological_process |
| GO:0045618 | positive regulation of keratinocyte differentiatio | IMP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0055086 | nucleobase-containing small molecule metabolic pro | TAS | biological_process |
| GO:0050679 | positive regulation of epithelial cell proliferati | IMP | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0001726 | ruffle | IDA | cellular_component |
| GO:0006165 | nucleoside diphosphate phosphorylation | IEA | biological_process |