Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DAPK3_HUMAN
Description:death-associated protein kinase 3 [Source:HGNC Symbol;Acc:2676]
Location:chr19 p13.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S311TIKSHsSLPPNSPXPhosphoSitePlus
T388QELLKtEALKRSPX; MEI4-Rec24PhosphoSitePlus
T225ETKQEtLTNISPkinasePhosphoSitePlus
T306RLKEYtIKSHSSPXPhosphoSitePlus
Y39GTGKEyAAKFIPkinasePhosphoSitePlus
T225ETKQEtLTNISDAPK3phosphoELM; RegPhos
T265PKRRMtIAQSLDAPK3phosphoELM; RegPhos
T180KNIFGtPEFVADAPK3phosphoELM; RegPhos
Y305TRLKEyTIKSHSPXPhosphoSitePlus
S311TIKSHsSLPPNDAPK3phosphoELM; RegPhos
S50KKRRLsSSRRGPkinasePhosphoSitePlus
S414LKRRFsRLENRSPXPhosphoSitePlus
T265PKRRMtIAQSLPkinasePhosphoSitePlus
T299RRRLKtTRLKESPXPhosphoSitePlus
T306RLKEYtIKSHSDAPK3phosphoELM; RegPhos
T299RRRLKtTRLKEDAPK3phosphoELM; RegPhos
T180KNIFGtPEFVAPkinasePhosphoSitePlus

Dephosphorylation site
DAPK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000301264P216SGreenman2007, HPILung Cancer17344846, 18428421, 17344846, 21487036, 17344846 21487036
ENSP00000301264D161NGreenman2007, HPIOvarian Cancer17344846, 18428421, 17344846 21487036
ENSP00000301264T112MHPIColorectal Cancer17344846 21487036
ENSP00000301264T112MGreenman2007Intestines Cancer17344846, 18428421, 17344846, 21487036

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000301264Gastric CancerMetastasiscell lineDown0.3117022644
ENSP00000301264Gastric CancerMetastasiscell lineDown0.3117022644

Hyperphosphorylation site
DAPK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DAPK3_HUMANMDM2_HUMANkinase -> substrateRegPhos
DAPK3_HUMANPP14A_HUMANkinase -> substrateRegPhos
DAPK3_HUMANDAPK3_HUMANkinase -> substrateRegPhos
DAPK3_HUMANCDN1A_HUMANkinase -> substrateHPRD; RegPhos
DAPK3_HUMANMYL9_HUMANkinase -> substrateRegPhos
DAPK3_HUMANH31_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05219Bladder cancer
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043522leucine zipper domain bindingIPImolecular_function
GO:0006917induction of apoptosisIDAbiological_process
GO:2001241positive regulation of extrinsic apoptotic signaliIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusISScellular_component
GO:0046777protein autophosphorylationTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0017148negative regulation of translationIDAbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0030182neuron differentiationIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0010506regulation of autophagyTASbiological_process
GO:0000910cytokinesisTASbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005815microtubule organizing centerIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0042981regulation of apoptotic processTASbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0007088regulation of mitosisTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0006940regulation of smooth muscle contractionTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016605PML bodyIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0016568chromatin modificationIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:2000249regulation of actin cytoskeleton reorganizationTASbiological_process
GO:0071346cellular response to interferon-gammaIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:2000145regulation of cell motilityTASbiological_process


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