Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:P63_HUMAN
Description:tumor protein p63 [Source:HGNC Symbol;Acc:15979]
Location:chr3 q28
Node attribute:TF; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T491QRNALtPTTIPPhosphoSitePlus
S479KLPSVsQLINPPhosphoSitePlus
Y18YCPDPyIQRFVPhosphoSitePlus
T329IVTLEtRDGQVHPRD
S358KADEDsIRKQQP53PhosphoSitePlus
Y171PSNTDyPGPHSP53PhosphoSitePlus
Y149TAPSPyAQPSSPhosphoSitePlus
Y36WKESYyRSTMSPhosphoSitePlus
S477MNKLPsVSQLIPhosphoSitePlus
Y13CATLQyCPDPYPhosphoSitePlus
T326ILIIVtLETRDHPRD
Y231RAMPVyKKAEHP53PhosphoSitePlus
S560RLGCSsCLDYFSAM_2PhosphoSitePlus
Y290SVLVPyEPPQVP53PhosphoSitePlus

Dephosphorylation site
P63_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376253T329PTCGAOvarian Cancer21720365, 18772890
ENSP00000264731P279HHPIColorectal Cancer10485447
ENSP00000394337P65SBIOMARTBreast Cancer21930507, 21930502
ENSP00000264731P133SCOSMICSkin Cancer21984974
ENSP00000264731P65SBIOMARTBreast Cancer21930507, 21930502
ENSP00000264731S81*COSMICHead and Neck Cancer21798893
ENSP00000264731T566MCOSMICHead and Neck Cancer21798893
ENSP00000264731A187PHPILung Cancer9662378
ENSP00000264731E328*Ding2008, COSMICLung Cancer18948947
ENSP00000376253M107LTCGAOvarian Cancer21720365, 18772890
ENSP00000264731M499ICOSMICMelanoma20016485
ENSP00000376253P65SBIOMARTBreast Cancer21930507, 21930502
ENSP00000371495P65SBIOMARTBreast Cancer21930507, 21930502
ENSP00000264731L74FCOSMICHead and Neck Cancer21798893
ENSP00000376253*556CCOSMICOvarian Cancer21720365
ENSP00000264731Q204LHPIUterine Cancer9662378
ENSP00000264731S184LHPI, COSMICHead and Neck Cancer9662378, 21798893
ENSP00000264731A190PCOSMICHead and Neck Cancer21798893
ENSP00000264731M107LCOSMICOvarian Cancer21720365
ENSP00000407144P65SBIOMARTBreast Cancer21930507, 21930502
ENSP00000317510P65SBIOMARTBreast Cancer21930507, 21930502
ENSP00000264731C244FDing2008, COSMICLung Cancer18948947
ENSP00000264731S560AHPIOvarian Cancer10485447
ENSP00000264731E609KCOSMICMelanoma21499247
ENSP00000264731M387ICOSMICMelanoma21499247
ENSP00000264731G269VDing2008, COSMICLung Cancer18948947
ENSP00000376254M405IBIOMARTMelanoma21930507, 21930502
ENSP00000264731S365LCOSMICMelanoma21499247
ENSP00000264731D170EDing2008, COSMICLung Cancer18948947
ENSP00000264731T329PCOSMICOvarian Cancer21720365

Differential expressed protein
P63_HUMAN is not differential expressed protein.

Hyperphosphorylation site
P63_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P63_HUMANP63_HUMANTF -> target geneTRANSFAC
P63_HUMANJAG1_HUMANTF -> target geneTRANSFAC
P63_HUMANCDN1A_HUMANTF -> target geneTRANSFAC
P63_HUMANMDM2_HUMANTF -> target geneTRANSFAC
P63_HUMAN1433S_HUMANTF -> target geneTRANSFAC
P53_HUMANP63_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
P63_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0010165response to X-rayIBAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0007569cell agingIEAbiological_process
GO:0009954proximal/distal pattern formationIEAbiological_process
GO:0006338chromatin remodelingIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0001736establishment of planar polarityIEAbiological_process
GO:0002064epithelial cell developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIBAmolecular_function
GO:0042771intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003684damaged DNA bindingIBAmolecular_function
GO:0006915apoptotic processIDAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0006978DNA damage response, signal transduction by p53 clIBAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000785chromatinIBAcellular_component
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0045747positive regulation of Notch signaling pathwayIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0043616keratinocyte proliferationIEAbiological_process
GO:0051289protein homotetramerizationIPIbiological_process
GO:0008544epidermis developmentIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:0042771intrinsic apoptotic signaling pathway in response IBAbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0060157urinary bladder developmentIEAbiological_process
GO:0034644cellular response to UVIBAbiological_process
GO:0007499ectoderm and mesoderm interactionIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0005829cytosolIBAcellular_component
GO:0003677DNA bindingNASmolecular_function
GO:0001942hair follicle developmentIEAbiological_process
GO:0051262protein tetramerizationIEAbiological_process
GO:0060513prostatic bud formationIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIBAmolecular_function
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0010259multicellular organismal agingIEAbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0060197cloacal septationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0043589skin morphogenesisIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0030425dendriteIBAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0060529squamous basal epithelial stem cell differentiatioIEAbiological_process
GO:0030850prostate gland developmentIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0048745smooth muscle tissue developmentIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045617negative regulation of keratinocyte differentiatioIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0036342post-anal tail morphogenesisIEAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0003682chromatin bindingIBAmolecular_function
GO:0007389pattern specification processIEAbiological_process
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0002039p53 bindingIBAmolecular_function
GO:0043523regulation of neuron apoptotic processIBAbiological_process
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0048807female genitalia morphogenesisIEAbiological_process
GO:0001738morphogenesis of a polarized epitheliumIEAbiological_process
GO:0045747positive regulation of Notch signaling pathwayIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIBAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0010332response to gamma radiationIBAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0030859polarized epithelial cell differentiationIEAbiological_process
GO:0031571mitotic cell cycle G1/S transition DNA damage checIBAbiological_process
GO:0051402neuron apoptotic processIEAbiological_process