Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD2A2_HUMAN
Description:cyclin-dependent kinase inhibitor 2A [Source:HGNC Symbol;Acc:1787]
Location:chr9 p21.3
Node attribute:PPI(source)

Phosphorylation site
CD2A2_HUMAN do not have phosphorylation site.

Dephosphorylation site
CD2A2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000432664*133KCOSMICMelanoma21499247
ENSP00000355153G166RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355153R123HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355153R139*COSMICIntestines Cancer
ENSP00000355153R139PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355153T136IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355153*174RCOSMICSkin Cancer21984974
ENSP00000355153R156LBIOMARTLung Cancer21930507, 21930502
ENSP00000355153H107LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355153R122QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355153R156LDing2008Lung Cancer18948947

Differential expressed protein
CD2A2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD2A2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CD2A2_HUMANMDM2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05218Melanoma
hsa05219Bladder cancer
hsa04110Cell cycle
hsa05200Pathways in cancer
hsa05214Glioma
hsa04115p53 signaling pathway
hsa05166HTLV-I infection
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05203Viral carcinogenesis
hsa05223Non-small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0090398cellular senescenceIMPbiological_process
GO:0007050cell cycle arrestIMPbiological_process
GO:0002039p53 bindingIPImolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006917induction of apoptosisIMPbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0006919activation of cysteine-type endopeptidase activityIMPbiological_process
GO:0043517positive regulation of DNA damage response, signalIDAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0031648protein destabilizationIDAbiological_process
GO:0030889negative regulation of B cell proliferationISSbiological_process
GO:0006469negative regulation of protein kinase activityIMPbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0006309apoptotic DNA fragmentationIMPbiological_process
GO:0051444negative regulation of ubiquitin-protein ligase acISSbiological_process
GO:0097371MDM2/MDM4 family protein bindingIPImolecular_function
GO:0048103somatic stem cell divisionISSbiological_process
GO:0033088negative regulation of immature T cell proliferatiISSbiological_process
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0006364rRNA processingIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0010389regulation of G2/M transition of mitotic cell cyclIMPbiological_process
GO:0055105ubiquitin-protein ligase inhibitor activityISSmolecular_function
GO:0033235positive regulation of protein sumoylationIMPbiological_process
GO:0050821protein stabilizationIDAbiological_process
GO:0071158positive regulation of cell cycle arrestIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0031647regulation of protein stabilityISSbiological_process
GO:0016604nuclear bodyIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0046825regulation of protein export from nucleusIMPbiological_process
GO:0008637apoptotic mitochondrial changesIMPbiological_process


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