Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATR_HUMAN
Description:ataxia telangiectasia and Rad3 related [Source:HGNC Symbol;Acc:882]
Location:chr3 q23
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S436RRRLSsSLNPSPhosphoSitePlus; HPRD
S1876SPGDSsQEDSLFAT; Mad3_BUB1_IPhosphoSitePlus
S441SSLNPsKRAPKPhosphoSitePlus
Y317NIEPVyLNMLLPhosphoSitePlus
S1007LAAKAsPAASAPhosphoSitePlus
T1989FPENEtPPEGKHPRD; phosphoELM; SysPTM
Y310FEAEAyRNIEPPhosphoSitePlus
S1871PLFQHsPGDSSFATPhosphoSitePlus
S2313KPKKIsLKGSDPhosphoSitePlus
Y1122ELMADyLQPKLUMEPhosphoSitePlus
S1154KMALNsLMSLMHPRD
S435KRRRLsSSLNPPhosphoSitePlus; HPRD
T1566QHTINtQDIASPhosphoSitePlus
T1989FPENEtPPEGKFATPhosphoSitePlus; SysPTM
Y2187VSKSSyPMRVNPhosphoSitePlus
Y26ATPEEyNTVVQPhosphoSitePlus
S2186AVSKSsYPMRVPhosphoSitePlus
S919LVAAKsVKLQSHPRD
T533PSVVItWMSLDPhosphoSitePlus
S1140NMQLLsSSVGIUMEPhosphoSitePlus
S1875HSPGDsSQEDSHPRD
S61VKKTDsQPTSVPhosphoSitePlus
S1645TLAVAsFRSKAPhosphoSitePlus
T1578LCQLStQTVFSPhosphoSitePlus
S549LKSCRsLLESVRAD17HPRD
T1275EYRKEtSESTDPhosphoSitePlus
T1589MLDHLtQWARHPhosphoSitePlus
Y291DQLKLyEEPLSPhosphoSitePlus
S437RRLSSsLNPSKPhosphoSitePlus; HPRD
S480ISLEYsGLKNPRAD17HPRD
S428NSDGIsPKRRRPhosphoSitePlus; HPRD

Dephosphorylation site
ATR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343741A1488PGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000343741E2537QGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000343741A2002GGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000343741K704*BIOMARTBreast Cancer21930507, 21930502
ENSP00000343741D798HBIOMARTBreast Cancer21930507, 21930502
ENSP00000343741S2233IHPINon-small cell lung carcinoma17344846
ENSP00000343741E2537QHPIbreast ductal carcinoma17344846
ENSP00000343741G2618EDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000372581D734HBIOMARTBreast Cancer21930507, 21930502
ENSP00000343741E2438KGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000372581K640*BIOMARTBreast Cancer21930507, 21930502
ENSP00000343741S2233IGreenman2007Lung Cancer16140923, 17344846, 18428421

Differential expressed protein
ATR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ATR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATR_HUMANE2F1_HUMANkinase -> substrateHPRD; RegPhos
ATR_HUMANXPA_HUMANkinase -> substrateRegPhos
ATR_HUMANH2AX_HUMANkinase -> substrateRegPhos
ATR_HUMANBRCA1_HUMANkinase -> substrateRegPhos
ATR_HUMANCHK2_HUMANkinase -> substrateRegPhos
ATR_HUMANMDM2_HUMANkinase -> substrateRegPhos
ATR_HUMANTREX1_HUMANkinase -> substrateHPRD
ATR_HUMANMCM7_HUMANkinase -> substrateRegPhos
ATR_HUMANCREB1_HUMANkinase -> substrateRegPhos
ATR_HUMANTBL2_HUMANkinase -> substrateRegPhos
RAD17_HUMANATR_HUMANkinase -> substrateHPRD
ATR_HUMANATRIP_HUMANkinase -> substrateRegPhos
ATR_HUMANCHK1_HUMANkinase -> substrateRegPhos
ATR_HUMANP53_HUMANkinase -> substrateRegPhos
ATR_HUMANSMC1A_HUMANkinase -> substrateRegPhos
ATR_HUMANRAD17_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03460Fanconi anemia pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006281DNA repairIEAbiological_process
GO:0000077DNA damage checkpointIEAbiological_process
GO:0008156negative regulation of DNA replicationIMPbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0001741XY bodyIEAcellular_component
GO:0043517positive regulation of DNA damage response, signalIMPbiological_process
GO:0032407MutSalpha complex bindingIDAmolecular_function
GO:0016605PML bodyIEAcellular_component
GO:0000077DNA damage checkpointIDAbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0090399replicative senescenceIMPbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043393regulation of protein bindingIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006974response to DNA damage stimulusTASbiological_process
GO:0032405MutLalpha complex bindingIDAmolecular_function
GO:0071480cellular response to gamma radiationIDAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0005694chromosomeISScellular_component
GO:0005488bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0034644cellular response to UVIMPbiological_process
GO:0007049cell cycleTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0006281DNA repairTASbiological_process