Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRAF6_HUMAN
Description:TNF receptor-associated factor 6, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:12036]
Location:chr11 p12
Node attribute:PPI(source); kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y326ETQSMyVSELKSpc7; Tropomyosin_1; MyosPhosphoSitePlus
Y353QCNGIyIWKIGHis_Phos_1PhosphoSitePlus
S507RFDMGsLRREGPhosphoSitePlus

Dephosphorylation site
TRAF6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337853R466WCOSMICOvarian Cancer21720365
ENSP00000337853A481TCOSMICOvarian Cancer21720365
ENSP00000433623A481TCOSMICOvarian Cancer21720365
ENSP00000433623R466WCOSMICOvarian Cancer21720365

Differential expressed protein
TRAF6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRAF6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRAF6_HUMANIRF7_HUMANkinase -> substrateKEGG
IL1R1_HUMANTRAF6_HUMANotherKEGG
TNR1A_HUMANTRAF6_HUMANotherKEGG
TRAF6_HUMANIRF5_HUMANotherKEGG
TRAF6_HUMANM3K7_HUMANotherKEGG
RIPK1_HUMANTRAF6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04621NOD-like receptor signaling pathway
hsa04380Osteoclast differentiation
hsa05133Pertussis
hsa05145Toxoplasmosis
hsa04010MAPK signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C
hsa04622RIG-I-like receptor signaling pathway
hsa05140Leishmaniasis
hsa05152Tuberculosis
hsa04722Neurotrophin signaling pathway
hsa05169Epstein-Barr virus infection
hsa04120Ubiquitin mediated proteolysis
hsa05162Measles
hsa04620Toll-like receptor signaling pathway
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa05168Herpes simplex infection
hsa04064NF-kappa B signaling pathway
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0043507positive regulation of JUN kinase activityIDAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0006461protein complex assemblyIEAbiological_process
GO:0051023regulation of immunoglobulin secretionIEAbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0009898internal side of plasma membraneISScellular_component
GO:0032743positive regulation of interleukin-2 productionIMPbiological_process
GO:0070555response to interleukin-1IDAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0005811lipid particleISScellular_component
GO:0007250activation of NF-kappaB-inducing kinase activityIMPbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005811lipid particleIEAcellular_component
GO:0031996thioesterase bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:2000679positive regulation of transcription regulatory reIDAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0046849bone remodelingIEAbiological_process
GO:0043011myeloid dendritic cell differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0009898internal side of plasma membraneIEAcellular_component
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0048468cell developmentIEAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045672positive regulation of osteoclast differentiationIDAbiological_process
GO:0035631CD40 receptor complexIEAcellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0000187activation of MAPK activityTASbiological_process
GO:0070534protein K63-linked ubiquitinationIGIbiological_process
GO:0043422protein kinase B bindingIPImolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0045410positive regulation of interleukin-6 biosynthetic IEAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0035631CD40 receptor complexISScellular_component
GO:0031398positive regulation of protein ubiquitinationNASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0042088T-helper 1 type immune responseIEAbiological_process
GO:0002726positive regulation of T cell cytokine productionIMPbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0001503ossificationIEAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0031666positive regulation of lipopolysaccharide-mediatedIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0031435mitogen-activated protein kinase kinase kinase binIPImolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0019886antigen processing and presentation of exogenous pIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0070534protein K63-linked ubiquitinationIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0051865protein autoubiquitinationTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0045453bone resorptionIEAbiological_process
GO:0045084positive regulation of interleukin-12 biosyntheticIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0001843neural tube closureIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0006955immune responseIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0030316osteoclast differentiationIEAbiological_process
GO:0016567protein ubiquitinationIEAbiological_process
GO:0032147activation of protein kinase activityIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0050870positive regulation of T cell activationICbiological_process
GO:0050852T cell receptor signaling pathwayIMPbiological_process