| UniProt/SwissProt ID: | NR2C2_HUMAN |
| Description: | nuclear receptor subfamily 2, group C, member 2 [Source:HGNC Symbol;Acc:7972] |
| Location: | chr3 p25.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S46 | VDASGsPKQQF | PhosphoSitePlus | |
| S117 | VTDSAsVERLL | HPRD | |
| T224 | SPLIAtPTFVA | PhosphoSitePlus; phosphoELM | |
| T13 | IQIIStDSAVA | HPRD | |
| S238 | RKDLRsPLIAT | HPRD | |
| T352 | SRDQStPIIEV | PhosphoSitePlus | |
| S351 | ISRDQsTPIIE | PhosphoSitePlus | |
| T243 | SPLIAtPTFVA | HPRD | |
| S12 | RIQIIsTDSAV | HPRD | |
| T371 | SRDQStPIIEV | HPRD | |
| S68 | KVILAsPETSS | PhosphoSitePlus | |
| S98 | VTDSAsVERLL | PhosphoSitePlus | |
| Y116 | PQVVEyCVVCG | zf-C4 | PhosphoSitePlus |
| S219 | RKDLRsPLIAT | PhosphoSitePlus; phosphoELM | |
| S19 | DSAVAsPQRIQ | PhosphoSitePlus; HPRD | |
| S65 | VDASGsPKQQF | HPRD | |
| S87 | KVILAsPETSS | HPRD | |
| T245 | LIATPtFVADK | HPRD | |
| S74 | QFILTsPDGAG | HPRD | |
| T226 | LIATPtFVADK | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| NR2C2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000320447 | D251G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| NR2C2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NR2C2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NR2C2_HUMAN | M3K7_HUMAN | kinase -> substrate | RegPhos |
| NR2C2_HUMAN | SMAD3_HUMAN | kinase -> substrate | RegPhos |
| NR2C2_HUMAN | IKKB_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| NR2C2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0046982 | protein heterodimerization activity | IDA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IDA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0040019 | positive regulation of embryonic development | IEA | biological_process |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0043401 | steroid hormone mediated signaling pathway | IEA | biological_process |
| GO:0021549 | cerebellum development | IEA | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0003707 | steroid hormone receptor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0048520 | positive regulation of behavior | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051321 | meiotic cell cycle | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |