| UniProt/SwissProt ID: | SYUG_HUMAN |
| Description: | synuclein, gamma (breast cancer-specific protein 1) [Source:HGNC Symbol;Acc:11141] |
| Location: | chr10 q23.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S124 | AEEAQsGGD | CaMK2_group | RegPhos; SysPTM |
| Y39 | KEGVMyVGAKT | Synuclein | PhosphoSitePlus |
| S51 | ENVVQsVTSVA | HPRD | |
| S124 | AEEAQsGGD | CK2_group | RegPhos; SysPTM |
| S124 | AEEAQsGGD | GPRK5 | RegPhos; SysPTM |
| S124 | AEEAQsGGD__ | Synuclein | PhosphoSitePlus; SysPTM |
| S124 | AEEAQsG | GRK5 | HPRD; SysPTM |
| S124 | AEEAQsG | phosphoELM; SysPTM | |
| S9 | FKKGFsIAKEG | Synuclein | PhosphoSitePlus |
| S124 | AEEAQsGGD | BARK1 | RegPhos; SysPTM |
| Dephosphorylation site |
| SYUG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| SYUG_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361087 | Prostate Cancer | Metastasis | tissue | Down | 0.18 | 18553995 | ENSP00000361087 | Hepatocellular Carcinoma | Metastasis | cell line | Down | 0.41 | 19016532 | ENSP00000361087 | Breast Cancer | Normal vs. Cancer | tissue | Down | 20560667 | ENSP00000361087 | Pancreatic Cancer | Treatment (Gemcitabine-sensitive vs. Gemcitabine-resistant) | cell line | Down | <0.01 | 20944110 | ENSP00000361087 | Pancreatic Cancer | Treatment (Gemcitabine-sensitive vs. Gemcitabine-resistant) | cell line | Up | 2.9 | 20944110 |
| Hyperphosphorylation site |
| SYUG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GRK5_HUMAN | SYUG_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ARBK1_HUMAN | SYUG_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| SYUG_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0002118 | aggressive behavior | IEA | biological_process |
| GO:0014059 | regulation of dopamine secretion | IEA | biological_process |
| GO:0043679 | axon terminus | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0071464 | cellular response to hydrostatic pressure | IEA | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0007268 | synaptic transmission | IEA | biological_process |
| GO:0050808 | synapse organization | IEA | biological_process |
| GO:0005819 | spindle | IEA | cellular_component |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0046928 | regulation of neurotransmitter secretion | IEA | biological_process |
| GO:0008344 | adult locomotory behavior | IEA | biological_process |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0042220 | response to cocaine | IEA | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0043014 | alpha-tubulin binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0048487 | beta-tubulin binding | IEA | molecular_function |