Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYUG_HUMAN
Description:synuclein, gamma (breast cancer-specific protein 1) [Source:HGNC Symbol;Acc:11141]
Location:chr10 q23.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S124AEEAQsGGDCaMK2_groupRegPhos; SysPTM
Y39KEGVMyVGAKTSynucleinPhosphoSitePlus
S51ENVVQsVTSVAHPRD
S124AEEAQsGGDCK2_groupRegPhos; SysPTM
S124AEEAQsGGDGPRK5RegPhos; SysPTM
S124AEEAQsGGD__SynucleinPhosphoSitePlus; SysPTM
S124AEEAQsGGRK5HPRD; SysPTM
S124AEEAQsGphosphoELM; SysPTM
S9FKKGFsIAKEGSynucleinPhosphoSitePlus
S124AEEAQsGGDBARK1RegPhos; SysPTM

Dephosphorylation site
SYUG_HUMAN do not have dephosphorylation site.

Mutation site
SYUG_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361087Prostate CancerMetastasistissueDown0.1818553995
ENSP00000361087Hepatocellular CarcinomaMetastasiscell lineDown0.4119016532
ENSP00000361087Breast CancerNormal vs. CancertissueDown20560667
ENSP00000361087Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineDown<0.0120944110
ENSP00000361087Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineUp2.920944110

Hyperphosphorylation site
SYUG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GRK5_HUMANSYUG_HUMANkinase -> substrateHPRD; RegPhos
ARBK1_HUMANSYUG_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
SYUG_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002118aggressive behaviorIEAbiological_process
GO:0014059regulation of dopamine secretionIEAbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0071464cellular response to hydrostatic pressureIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0050808synapse organizationIEAbiological_process
GO:0005819spindleIEAcellular_component
GO:0005815microtubule organizing centerIEAcellular_component
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0042220response to cocaineIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0043014alpha-tubulin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0048487beta-tubulin bindingIEAmolecular_function


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