Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GNA12_HUMAN
Description:guanine nucleotide binding protein (G protein) alpha 12 [Source:HGNC Symbol;Acc:4380]
Location:chr7 p22.2
Node attribute:substrate; Gprotein; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y121GIPWQySENEKG-alphaPhosphoSitePlus
S68LGAGEsGKSTFG-alphaPhosphoSitePlus

Dephosphorylation site
GNA12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000275364P118LCOSMICMelanoma20424519
ENSP00000275364R235HCOSMICOvarian Cancer21720365
ENSP00000275364D113GCOSMICHead and Neck Cancer21798893
ENSP00000275364R235HCOSMICOvarian Cancer21720365
ENSP00000275364D113GCOSMICHead and Neck Cancer21798893

Differential expressed protein
GNA12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GNA12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CASR_HUMANGNA12_HUMANGPCR -> GproteingpDB
LPAR3_HUMANGNA12_HUMANGPCR -> GproteingpDB
GALR2_HUMANGNA12_HUMANGPCR -> GproteingpDB
S1PR3_HUMANGNA12_HUMANGPCR -> GproteingpDB
C3AR_HUMANGNA12_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNA12_HUMANGPCR -> GproteingpDB
5HT2C_HUMANGNA12_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNA12_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNA12_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNA12_HUMANGPCR -> GproteingpDB
S1PR2_HUMANGNA12_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNA12_HUMANGPCR -> GproteingpDB
S1PR5_HUMANGNA12_HUMANGPCR -> GproteingpDB
TA2R_HUMANGNA12_HUMANGPCR -> GproteingpDB
LPAR2_HUMANGNA12_HUMANGPCR -> GproteingpDB
ADA1A_HUMANGNA12_HUMANGPCR -> GproteingpDB
DRD5_HUMANGNA12_HUMANGPCR -> GproteingpDB
ACM3_HUMANGNA12_HUMANGPCR -> GproteingpDB
5HT4R_HUMANGNA12_HUMANGPCR -> GproteingpDB
GNA12_HUMANRASA2_HUMANGprotein -> effectorgpDB
GNA12_HUMANARHG1_HUMANGprotein -> effectorgpDB
GNA12_HUMANCADH1_HUMANGprotein -> effectorgpDB
GNA12_HUMANARHGC_HUMANGprotein -> effectorgpDB
GNA12_HUMANARHGB_HUMANGprotein -> effectorgpDB
ACK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
KS6B2_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
STYK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
AVR2A_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
PXK_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
IRAK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
GNA12_HUMANRASA2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04730Long-term depression
hsa04270Vascular smooth muscle contraction
hsa04810Regulation of actin cytoskeleton
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0031683G-protein beta/gamma-subunit complex bindingIBAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0031526brush border membraneIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007266Rho protein signal transductionIBAbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0006184GTP catabolic processIBAbiological_process
GO:0031234extrinsic to internal side of plasma membraneIBAcellular_component
GO:0003924GTPase activityIBAmolecular_function
GO:0004871signal transducer activityIBAmolecular_function
GO:0005834heterotrimeric G-protein complexIBAcellular_component
GO:0007188adenylate cyclase-modulating G-protein coupled recIBAbiological_process
GO:0031752D5 dopamine receptor bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0008360regulation of cell shapeIEAbiological_process
GO:0031752D5 dopamine receptor bindingIBAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0031526brush border membraneIBAcellular_component
GO:0019001guanyl nucleotide bindingIEAmolecular_function


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