| UniProt/SwissProt ID: | PQBP1_HUMAN |
| Description: | polyglutamine binding protein 1 [Source:HGNC Symbol;Acc:9330] |
| Location: | chrX p11.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y33 | IIAEDyDDDPV | PhosphoSitePlus | |
| S152 | QRPYPsPGAVL | HPRD | |
| S94 | AKKLRsSNADA | PhosphoSitePlus; HPRD | |
| S210 | DPSSYsDAPRG | PhosphoSitePlus | |
| Y209 | MDPSSySDAPR | PhosphoSitePlus | |
| Y150 | FQQRPyPSPGA | HPRD | |
| Y146 | DRERGyDKVDR | PhosphoSitePlus | |
| Y245 | FQQRPyPSPGA | HPRD; phosphoELM | |
| S247 | QRPYPsPGAVL | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| PQBP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365747 | R224W | HPI | Colorectal Cancer | 16959974 | ENSP00000391759 | R224W | HPI | Colorectal Cancer | 16959974 | ENSP00000379985 | R224W | HPI | Colorectal Cancer | 16959974 | ENSP00000218224 | D129G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000365747 | D129G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379985 | D129G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000365747 | R224W | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000391759 | R224W | COSMIC | Intestines Cancer | 16959974 | ENSP00000218224 | R224W | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000379985 | R224W | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000391759 | D129G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PQBP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PQBP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ARBK1_HUMAN | PQBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | PQBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PQBP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0034063 | stress granule assembly | IDA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0071598 | neuronal ribonucleoprotein granule | IEA | cellular_component |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0010494 | cytoplasmic stress granule | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |