Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYUB_HUMAN
Description:synuclein, beta [Source:HGNC Symbol;Acc:11140]
Location:chr5 q35.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S118EPEGEsYEDPPCK2_groupRegPhos
S118EPEGEsYEDPPGRK5HPRD
Y127PPQEEyQEYEPPhosphoSitePlus
S118EPEGEsYEDPPSynucleinPhosphoSitePlus
S118EPEGEsYEDPPBARK1RegPhos
S118EPEGEsYEDPPGPRK5RegPhos
Y39KEGVLyVGSKTSynucleinPhosphoSitePlus
S118EPEGEsYEDPPGPRK5(GRK5RegPhos

Dephosphorylation site
SYUB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377296E109KCOSMICOvarian Cancer21720365
ENSP00000377296G82RCOSMICHead and Neck Cancer21984974

Differential expressed protein
SYUB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SYUB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARBK1_HUMANSYUB_HUMANkinase -> substrateRegPhos
GRK5_HUMANSYUB_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
SYUB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005794Golgi apparatusIDAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0050808synapse organizationIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0004859phospholipase inhibitor activityTASmolecular_function
GO:0043195terminal buttonIEAcellular_component
GO:0007268synaptic transmissionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005509calcium ion bindingIDAmolecular_function
GO:0043014alpha-tubulin bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0030426growth coneIEAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0048487beta-tubulin bindingIEAmolecular_function
GO:0042417dopamine metabolic processIEAbiological_process
GO:0045202synapseIEAcellular_component


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