Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACM3_HUMAN
Description:cholinergic receptor, muscarinic 3 [Source:HGNC Symbol;Acc:1952]
Location:chr1 q43
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S291SSRSCsSYELQ7tm_1PhosphoSitePlus
S366TRAIYsIVLKL7tm_1PhosphoSitePlus
Y365ETRAIySIVLK7tm_1PhosphoSitePlus

Dephosphorylation site
ACM3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000255380M122IBIOMARTBreast Cancer21930507, 21930502
ENSP00000255380P421LCOSMICMelanoma21946352
ENSP00000255380W200*COSMICMelanoma21946352
ENSP00000255380F581ICOSMICMelanoma21946352
ENSP00000255380G32RCOSMICMelanoma21946352
ENSP00000255380V443ICOSMICOvarian Cancer21720365
ENSP00000255380N444HCOSMICMelanoma21946352
ENSP00000255380V161FTCGAOvarian Cancer21720365, 18772890
ENSP00000255380P428SCOSMICMelanoma21946352
ENSP00000255380V443ITCGAOvarian Cancer21720365, 18772890
ENSP00000255380V161FCOSMICOvarian Cancer21720365
ENSP00000255380D387HTCGAOvarian Cancer21720365, 18772890
ENSP00000255380T258ICOSMICSkin Cancer21984974
ENSP00000255380D387HCOSMICOvarian Cancer21720365
ENSP00000255380S25FCOSMICMelanoma21946352

Differential expressed protein
ACM3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ACM3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLAT_HUMANACM3_HUMANligand -> receptorHPMR
ACM3_HUMANGNAQ_HUMANGPCR -> GproteingpDB
ACM3_HUMANGNA11_HUMANGPCR -> GproteingpDB
ACM3_HUMANGNA13_HUMANGPCR -> GproteingpDB
ACM3_HUMANGNA12_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04972Pancreatic secretion
hsa04020Calcium signaling pathway
hsa04725Cholinergic synapse
hsa04080Neuroactive ligand-receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa04971Gastric acid secretion
hsa04970Salivary secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0006939smooth muscle contractionIEAbiological_process
GO:0032279asymmetric synapseIEAcellular_component
GO:0008283cell proliferationTASbiological_process
GO:0007213G-protein coupled acetylcholine receptor signalingIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0003056regulation of vascular smooth muscle contractionIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0016907G-protein coupled acetylcholine receptor activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0042166acetylcholine bindingIEAmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0007586digestionIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0006464cellular protein modification processTASbiological_process
GO:0019229regulation of vasoconstrictionIEAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0004435phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0030425dendriteIEAcellular_component
GO:0045987positive regulation of smooth muscle contractionIEAbiological_process
GO:0050796regulation of insulin secretionTASbiological_process