Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CADH1_HUMAN
Description:cadherin 1, type 1, E-cadherin (epithelial) [Source:HGNC Symbol;Acc:1748]
Location:chr16 q22.1
Node attribute:effector; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S844GSEAAsLSSLNCadherin_CPhosphoSitePlus
T748PPEDDtRDNVYCadherin_CPhosphoSitePlus
S840YEGSGsEAASLRegPhos
T211IIEREtGWLKVCadherinPhosphoSitePlus
S847AASLSsLNSSEGSK3BHPRD; RegPhos
S851SSLNSsESDKDCK2a1-rsRegPhos
S847AASLSsLNSSECSNK2A1HPRD
S840YEGSGsEAASLCadherin_CPhosphoSitePlus
S847AASLSsLNSSECK2a1-rsRegPhos
S770QDFDLsQLHRGCadherin_CPhosphoSitePlus
Y797MSVPRyLPRPACadherin_CPhosphoSitePlus
S847AASLSsLNSSECadherin_CPhosphoSitePlus
Y753TRDNVyYYDEECadherin_CPhosphoSitePlus
S846EAASLsSLNSSRegPhos
S838FDYEGsGSEAACK2a1-rsRegPhos
S853LNSSEsDKDQDCK2a1RegPhos
Y876KLADMyGGGEDCadherin_CPhosphoSitePlus
S838FDYEGsGSEAACSNK2A1HPRD
S853LNSSEsDKDQDCSNK2A1HPRD
S851SSLNSsESDKDCK2a1RegPhos
S838FDYEGsGSEAACK2a1RegPhos
Y68RQRTAyFSLDTCadherin_proPhosphoSitePlus
S850LSSLNsSESDKCadherin_CPhosphoSitePlus
T330VISVVtTGLDRCadherinPhosphoSitePlus
Y755DNVYYyDEEGGCadherin_CPhosphoSitePlus
S838FDYEGsGSEAACadherin_CPhosphoSitePlus
S851SSLNSsESDKDCK2_groupphosphoELM; RegPhos
T395NVVITtLKVTDCadherinPhosphoSitePlus
S844GSEAAsLSSLNCK1_deltaphosphoELM
S838FDYEGsGSEAARegPhos
S70RTAYFsLDTRFCadherin_proPhosphoSitePlus
S853LNSSEsDKDQDCK2a1-rsRegPhos
T66TGRQRtAYFSLCadherin_proPhosphoSitePlus
T576GSPVAtGTGTLCadherinPhosphoSitePlus
S853LNSSEsDKDQDCadherin_CPhosphoSitePlus
S847AASLSsLNSSECK2a1RegPhos
S851SSLNSsESDKDCSNK2A1HPRD
T394ANVVItTLKVTCadherinPhosphoSitePlus
Y754RDNVYyYDEEGCadherin_CPhosphoSitePlus

Dephosphorylation site
CADH1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261769L581PCOSMICGastric Cancer10211998
ENSP00000261769E353*COSMICGastric Cancer10211998
ENSP00000261769R154fs*61COSMICBreast Cancer8934538
ENSP00000261769E58*COSMICBreast Cancer21512767
ENSP00000261769G62DCOSMICBreast Cancer15696125
ENSP00000261769D370HCOSMICGastric Cancer10211998
ENSP00000261769S543fs*14COSMICBreast Cancer11291078
ENSP00000261769A617TOMIM, COSMICUterine Cancer8075649 12588804
ENSP00000261769S846TCOSMICOther Cancer10891567
ENSP00000261769A709TCOSMICBreast Cancer15696125
ENSP00000261769S851LCOSMICBreast Cancer11322170
ENSP00000261769I300MCOSMICBiliary Tract Cancer11241409
ENSP00000261769A634VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000261769S838GOMIM, COSMIC, HPIOvarian Cancer8075649, 9744472 8075649
ENSP00000261769A298DCOSMICBreast Cancer11322170
ENSP00000261769E504*COSMICBreast Cancer8557030
ENSP00000261769T340ACOSMICSarcoma14562278
ENSP00000261769D402NCOSMICGastric Cancer10211998
ENSP00000261769T340AOMIMGastric Cancer11968083 12588804
ENSP00000261769H121fs*94COSMICEsophageal Cancer10408414
ENSP00000261769H92YCOSMICBreast Cancer15696125
ENSP00000261769V473DHPI, COSMICGastric Cancer8033105 9744472
ENSP00000261769W409fs*8COSMICBreast Cancer8934538
ENSP00000261769D244GHPIGastric Cancer9744472 10319582
ENSP00000261769D805fs*11COSMICBreast Cancer15696125
ENSP00000261769M282IHPI, COSMICBreast Cancer9744472 17224074, 11857408
ENSP00000261769E490KBIOMARTBreast Cancer21930507, 21930502
ENSP00000261769Y523*BIOMARTBreast Cancer21930507, 21930502
ENSP00000261769M316VTCGAOvarian Cancer21720365, 18772890
ENSP00000261769D254YCOSMICBreast Cancer15696125
ENSP00000261769D777NHPIBreast Cancer9744472 17224074
ENSP00000261769N613fs*18COSMICBreast Cancer12800196
ENSP00000261769V365LCOSMICGastric Cancer10211998
ENSP00000261769P309SCOSMICBiliary Tract Cancer11241409
ENSP00000261769T295ICOSMICBiliary Tract Cancer11241409
ENSP00000261769E386*COSMICBreast Cancer8557030
ENSP00000261769H121RCOSMICBreast Cancer15696125
ENSP00000261769D858ECOSMICHead and Neck Cancer21798893
ENSP00000261769I615fs*16COSMICBreast Cancer8934538
ENSP00000261769D479GCOSMICGastric Cancer10211998
ENSP00000261769F423fs*8COSMICBreast Cancer11196175
ENSP00000261769A634VCOSMICCentral Nervous System Neoplasms18772890
ENSP00000261769A347VCOSMICGastric Cancer10211998
ENSP00000261769H123YHPI, COSMICGastric Cancer9744472, 10094558
ENSP00000261769A617TOMIMGastric Cancer8075649 12588804
ENSP00000261769P201fs*14COSMICIntestines Cancer12096341
ENSP00000261769W638*COSMICBreast Cancer
ENSP00000261769W20*COSMICBreast Cancer10094558
ENSP00000261769A634VOMIMGastric Cancer12588804
ENSP00000261769P30TCOSMICBreast Cancer12800196
ENSP00000261769Q699*COSMICGastric Cancer16610016
ENSP00000261769E261*COSMICBreast Cancer8557030
ENSP00000261769R598QHPI, COSMICGastric Cancer9744472, 10094558
ENSP00000261769A408VCOSMICGastric Cancer22152101
ENSP00000261769P126fs*89COSMICGastric Cancer17376510
ENSP00000261769M316VCOSMICOvarian Cancer21720365
ENSP00000261769V832MHPIGastric Cancer9744472 12216071 19268661 19017792 17510211 17668349
ENSP00000261769D308NCOSMICBreast Cancer11322170
ENSP00000261769T330ICOSMICBreast Cancer15696125
ENSP00000261769T522ICOSMICBreast Cancer19593635
ENSP00000261769R774KCOSMICBreast Cancer11322170
ENSP00000261769L711VOMIM, COSMICUterine Cancer8075649
ENSP00000261769Q448*BIOMARTBreast Cancer21930507, 21930502
ENSP00000261769R492IBIOMARTBreast Cancer21930507, 21930502
ENSP00000261769R74*COSMICBreast Cancer
ENSP00000261769Q677fs*2COSMICBreast Cancer10094558
ENSP00000261769I600MCOSMICBreast Cancer15696125
ENSP00000261769N428DCOSMICSarcoma20840677
ENSP00000261769P245LCOSMICBreast Cancer11322170
ENSP00000261769D370AHPIGastric Cancer8033105 9744472 15311212 15259055 11846558
ENSP00000261769D552NCOSMICBreast Cancer20668451
ENSP00000261769W532*COSMICBreast Cancer15696125
ENSP00000261769V55LCOSMICBreast Cancer21512767
ENSP00000261769T560RBIOMARTBreast Cancer21930507, 21930502
ENSP00000261769N369DCOSMICGastric Cancer10211998
ENSP00000261769V487AHPIGastric Cancer9744472 10319582
ENSP00000261769H233QCOSMICBreast Cancer19593635
ENSP00000261769S337fs*19COSMICGastric Cancer9045944
ENSP00000261769Q255*COSMICBreast Cancer11322170
ENSP00000261769L658fs*1COSMICBreast Cancer8934538
ENSP00000261769E243*COSMICBreast Cancer19593635
ENSP00000261769P260LCOSMICBreast Cancer11322170
ENSP00000261769N315SHPI, COSMICBreast Cancer9744472 7961105
ENSP00000261769N622fs*9COSMICBreast Cancer8934538
ENSP00000261769A286TCOSMICBreast Cancer11322170
ENSP00000261769D400YCOSMICGastric Cancer10211998
ENSP00000261769A592THPIThyroid Carcinoma9744472 8985087 11562785 11948460 11747475 11305955
ENSP00000261769A592TCOSMICGastric Cancer11598162
ENSP00000261769T193PHPI, COSMICGastric Cancer9744472 8797891
ENSP00000261769G571SCOSMICBreast Cancer11291078
ENSP00000261769D334HCOSMICGastric Cancer10211998
ENSP00000261769V832MOMIMGastric Cancer12216071
ENSP00000261769T357ICOSMICBiliary Tract Cancer11241409
ENSP00000261769E463QHPI, COSMICGastric Cancer9744472, 10094558
ENSP00000261769Q346*COSMICBreast Cancer8934538
ENSP00000261769Q23*COSMICBreast Cancer10094558
ENSP00000261769S559NCOSMICBreast Cancer15696125
ENSP00000261769L343fs*13COSMICGastric Cancer10211998
ENSP00000261769P740SCOSMICBreast Cancer11322170
ENSP00000261769V456MCOSMICBreast Cancer15696125
ENSP00000261769R335*COSMICBreast Cancer8934538
ENSP00000261769A692VCOSMICBreast Cancer15696125
ENSP00000261769E494*BIOMARTBreast Cancer21930507, 21930502
ENSP00000261769D257GCOSMICBreast Cancer11322170

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261769Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp2.120804217
ENSP00000261769Breast CancerMetastasiscell lineDown18729497

Hyperphosphorylation site
CADH1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA12_HUMANCADH1_HUMANGprotein -> effectorgpDB
GNA13_HUMANCADH1_HUMANGprotein -> effectorgpDB
TOPRS_HUMANCADH1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05100Bacterial invasion of epithelial cells
hsa04514Cell adhesion molecules (CAMs)
hsa05218Melanoma
hsa05200Pathways in cancer
hsa05213Endometrial cancer
hsa04520Adherens junction
hsa05219Bladder cancer
hsa05130Pathogenic Escherichia coli infection
hsa05216Thyroid cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051260protein homooligomerizationIEAbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0045295gamma-catenin bindingIPImolecular_function
GO:0005911cell-cell junctionIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0001829trophectodermal cell differentiationIEAbiological_process
GO:0043219lateral loopIEAcellular_component
GO:0030054cell junctionTAScellular_component
GO:0005925focal adhesionIDAcellular_component
GO:2000008regulation of protein localization to cell surfaceIEAbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0070830tight junction assemblyIEAbiological_process
GO:0060662salivary gland cavitationIEAbiological_process
GO:0043296apical junction complexIDAcellular_component
GO:0071285cellular response to lithium ionIDAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0032880regulation of protein localizationIEAbiological_process
GO:0034332adherens junction organizationTASbiological_process
GO:0042993positive regulation of transcription factor importIDAbiological_process
GO:0043220Schmidt-Lanterman incisureIEAcellular_component
GO:0033561regulation of water loss via skinIEAbiological_process
GO:0071681cellular response to indole-3-methanolIDAbiological_process
GO:0008013beta-catenin bindingIDAmolecular_function
GO:0060693regulation of branching involved in salivary glandIEAbiological_process
GO:0030506ankyrin bindingIPImolecular_function
GO:0016337cell-cell adhesionIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0016021integral to membraneIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0016328lateral plasma membraneIDAcellular_component
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0007605sensory perception of soundIEAbiological_process
GO:0090102cochlea developmentIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005768endosomeIEAcellular_component
GO:0021983pituitary gland developmentIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0050776regulation of immune responseTASbiological_process
GO:0009898internal side of plasma membraneIDAcellular_component
GO:0072659protein localization to plasma membraneIDAbiological_process
GO:0005912adherens junctionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0071944cell peripheryIEAcellular_component
GO:0045177apical part of cellIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0007416synapse assemblyIEAbiological_process
GO:0007156homophilic cell adhesionNASbiological_process
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0009636response to toxinIEAbiological_process
GO:0016235aggresomeIDAcellular_component
GO:0032794GTPase activating protein bindingIPImolecular_function
GO:0033268node of RanvierIEAcellular_component
GO:0050839cell adhesion molecule bindingNASmolecular_function
GO:0016342catenin complexIDAcellular_component
GO:0043679axon terminusIEAcellular_component
GO:0019538protein metabolic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0022408negative regulation of cell-cell adhesionIMPbiological_process
GO:0005913cell-cell adherens junctionIDAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0043281regulation of cysteine-type endopeptidase activityIEAbiological_process
GO:0016337cell-cell adhesionIDAbiological_process
GO:0045216cell-cell junction organizationTASbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005802trans-Golgi networkIMPcellular_component