| UniProt/SwissProt ID: | ARHGB_HUMAN |
| Description: | Rho guanine nucleotide exchange factor (GEF) 11 [Source:HGNC Symbol;Acc:14580] |
| Location: | chr1 q23.1 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T294 | LDSPRtSPVIM | HPRD | |
| T708 | SLENPtPPFTP | HPRD | |
| S29 | ERKSPsHHRQP | PhosphoSitePlus | |
| S1497 | SLGGEsSGGTT | HPRD | |
| S1295 | PRTRNsGIWES | PhosphoSitePlus; HPRD; phosphoELM | |
| S1491 | PLASDsRNSHE | HPRD; phosphoELM | |
| S1457 | SLGGEsSGGTT | PhosphoSitePlus; HPRD; phosphoELM | |
| T672 | PTPPFtPKMGR | PhosphoSitePlus; HPRD; phosphoELM | |
| S675 | VPRSRsDVDMD | HPRD | |
| T1515 | EAARWtDGSLS | HPRD | |
| S285 | RNSVLsDPGLD | HPRD | |
| S614 | LGRSEsLKGRE | PhosphoSitePlus | |
| T1475 | EAARWtDGSLS | PhosphoSitePlus; HPRD; phosphoELM | |
| S663 | SLSTRsLENPT | PhosphoSitePlus; HPRD; phosphoELM | |
| S1466 | TTPVGsFHTEA | HPRD; phosphoELM | |
| S1529 | KEPLAsDSRNS | HPRD | |
| T712 | PTPPFtPKMGR | HPRD | |
| T1063 | ELVALtSSDKN | PhosphoSitePlus | |
| S429 | TLGLGsLYGEN | RGS-like | PhosphoSitePlus |
| S1480 | TDGSLsPPAKE | PhosphoSitePlus; HPRD; phosphoELM | |
| S271 | HRRQGsDAAVP | PhosphoSitePlus | |
| S1064 | LVALTsSDKNT | PhosphoSitePlus | |
| S1155 | PEQEGsAEEEE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S291 | DPGLDsPRTSP | HPRD | |
| T1502 | SSGGTtPVGSF | HPRD | |
| S1300 | SGIWEsPELDR | PhosphoSitePlus; HPRD; phosphoELM | |
| S1489 | KEPLAsDSRNS | HPRD; phosphoELM | |
| S556 | FHIPLsPVEVK | PhosphoSitePlus | |
| T1501 | ESSGGtTPVGS | HPRD | |
| T41 | DASETtGLVQR | PhosphoSitePlus | |
| S1335 | PRTRNsGIWES | HPRD | |
| S589 | GTQRLsTGSFP | PhosphoSitePlus | |
| S635 | VPRSRsDVDMD | PhosphoSitePlus; HPRD | |
| S35 | HHRQPsDASET | PhosphoSitePlus; HPRD | |
| S245 | RNSVLsDPGLD | PhosphoSitePlus; HPRD; phosphoELM | |
| S255 | DSPRTsPVIMA | PhosphoSitePlus; HPRD; phosphoELM | |
| T40 | SDASEtTGLVQ | PhosphoSitePlus | |
| S1458 | LGGESsGGTTP | PhosphoSitePlus; HPRD; phosphoELM | |
| S1520 | TDGSLsPPAKE | HPRD | |
| S1340 | SGIWEsPELDR | HPRD | |
| T1461 | ESSGGtTPVGS | PhosphoSitePlus; HPRD; phosphoELM | |
| S1498 | LGGESsGGTTP | HPRD | |
| S38 | QPSDAsETTGL | PhosphoSitePlus | |
| S1195 | PEQEGsAEEEE | HPRD | |
| T254 | LDSPRtSPVIM | PhosphoSitePlus; HPRD; phosphoELM | |
| S27 | APERKsPSHHR | PhosphoSitePlus | |
| S592 | RLSTGsFPEDL | PhosphoSitePlus | |
| S251 | DPGLDsPRTSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S1065 | VALTSsDKNTW | PhosphoSitePlus | |
| S1506 | TTPVGsFHTEA | HPRD | |
| S1478 | RWTDGsLSPPA | PhosphoSitePlus | |
| S703 | SLSTRsLENPT | HPRD | |
| S1531 | PLASDsRNSHE | HPRD | |
| S295 | DSPRTsPVIMA | HPRD | |
| T668 | SLENPtPPFTP | PhosphoSitePlus; HPRD; phosphoELM | |
| T1462 | SSGGTtPVGSF | PhosphoSitePlus; HPRD; phosphoELM | |
| S1312 | R.NLAEDASSTEAAGGYKVVRK.A | SysPTM 2.0 | |
| Dephosphorylation site |
| ARHGB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357177 | R246S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000357177 | I1096L | COSMIC | Pancreatic Cancer | ENSP00000357177 | D1350N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000357177 | R702T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000357177 | H1133Y | COSMIC | Skin Cancer | 21984974 | ENSP00000357177 | T1002K | COSMIC | Skin Cancer | 21984974 | ENSP00000357177 | F382L | COSMIC | Melanoma | 21499247 | ENSP00000354644 | R206S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000354644 | V243I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000357177 | P1276S | COSMIC | Lung Cancer |
| Differential expressed protein |
| ARHGB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ARHGB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNA13_HUMAN | ARHGB_HUMAN | Gprotein -> effector | gpDB |
| GNAQ_HUMAN | ARHGB_HUMAN | Gprotein -> effector | gpDB |
| GNA12_HUMAN | ARHGB_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04270 | Vascular smooth muscle contraction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006928 | cellular component movement | NAS | biological_process |
| GO:0006941 | striated muscle contraction | NAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007266 | Rho protein signal transduction | IDA | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0030010 | establishment of cell polarity | NAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005622 | intracellular | IC | cellular_component |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0000910 | cytokinesis | NAS | biological_process |
| GO:0001558 | regulation of cell growth | NAS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0030036 | actin cytoskeleton organization | NAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0001664 | G-protein coupled receptor binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |