Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AVR2A_HUMAN
Description:activin A receptor, type IIA [Source:HGNC Symbol;Acc:173]
Location:chr2 q22.3
Node attribute:kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T486QMQRLtNIITTPhosphoSitePlus
Y215QLLNEyVAVKIPkinasePhosphoSitePlus

Dephosphorylation site
AVR2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384338C16*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000241416C16*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000384338D306NGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000241416K315NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000241416D306NGreenman2007, HPIGastric Cancer17344846, 18428421

Differential expressed protein
AVR2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AVR2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INHBA_HUMANAVR2A_HUMANligand -> receptorHPMR
NODAL_HUMANAVR2A_HUMANligand -> receptorHPMR
INHBB_HUMANAVR2A_HUMANligand -> receptorHPMR
BMP7_HUMANAVR2A_HUMANligand -> receptorHPMR
INHA_HUMANAVR2A_HUMANligand -> receptorHPMR
AVR2A_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
NODAL_HUMANAVR2A_HUMANotherKEGG
INHBA_HUMANAVR2A_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009986cell surfaceIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034673inhibin-betaglycan-ActRII complexIDAcellular_component
GO:0043084penile erectionIEAbiological_process
GO:0007178transmembrane receptor protein serine/threonine kiTASbiological_process
GO:0032927positive regulation of activin receptor signaling IDAbiological_process
GO:0048706embryonic skeletal system developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0030501positive regulation of bone mineralizationIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0007498mesoderm developmentIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0034711inhibin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0009966regulation of signal transductionIEAbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIMPbiological_process
GO:0019838growth factor bindingIEAmolecular_function
GO:0043621protein self-associationIEAmolecular_function
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0015026coreceptor activityIDAmolecular_function
GO:0060011Sertoli cell proliferationIEAbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0050999regulation of nitric-oxide synthase activityIEAbiological_process
GO:0017002activin-activated receptor activityIEAmolecular_function
GO:0008584male gonad developmentIEAbiological_process
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004675transmembrane receptor protein serine/threonine kiTASmolecular_function
GO:0042713sperm ejaculationIEAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0048185activin bindingIEAmolecular_function
GO:0045648positive regulation of erythrocyte differentiationIDAbiological_process
GO:0004674protein serine/threonine kinase activityEXPmolecular_function
GO:0030510regulation of BMP signaling pathwayIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function


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