| UniProt/SwissProt ID: | ARHGC_HUMAN |
| Description: | Rho guanine nucleotide exchange factor (GEF) 12 [Source:HGNC Symbol;Acc:14193] |
| Location: | chr11 q23.3 |
| Node attribute: | PPI(target); effector; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S608 | PPRRPsRHDNS | PhosphoSitePlus | |
| Y546 | SSTMQyVILMY | RGS-like | PhosphoSitePlus; SysPTM |
| T1286 | FPRYRtASQGP | PhosphoSitePlus; HPRD; phosphoELM | |
| S635 | LSTPSsVSPEP | PhosphoSitePlus | |
| S41 | VERIAsHDFDP | PhosphoSitePlus; phosphoELM | |
| Y1004 | LKLSEyPNVEE | PhosphoSitePlus | |
| Y1326 | DIATCySPRTS | PhosphoSitePlus | |
| T532 | EEVLMtAQAVE | RGS-like | PhosphoSitePlus |
| Y660 | GTDAGyLPANS | PhosphoSitePlus | |
| T632 | PKHLStPSSVS | PhosphoSitePlus | |
| Y551 | YVILMyMKHLG | RGS-like | PhosphoSitePlus |
| S1288 | RYRTAsQGPQT | PhosphoSitePlus; HPRD; phosphoELM | |
| S1544 | KHSDKs_____ | PhosphoSitePlus | |
| Y1524 | KVEESyTILCQ | PhosphoSitePlus | |
| S22 | PIRHGsILNRE | HPRD; SysPTM | |
| S637 | TPSSVsPEPQD | PhosphoSitePlus; HPRD | |
| S341 | QSLVGsPSTRI | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S190 | MERITsPVLMG | HPRD | |
| Y1284 | QHFPRyRTASQ | PhosphoSitePlus | |
| S1541 | LTDKHsDKS__ | PhosphoSitePlus | |
| S337 | DTDTQsLVGSP | PhosphoSitePlus | |
| S1170 | EQHGIsVTGLQ | PhosphoSitePlus | |
| T1525 | VEESYtILCQR | PhosphoSitePlus | |
| S1072 | ASTADsKHTFS | PhosphoSitePlus | |
| Y546 | SSTMQyVILMY | HPRD; SysPTM | |
| S1273 | GLTEKsVQEDW | PhosphoSitePlus | |
| S1327 | IATCYsPRTST | PhosphoSitePlus | |
| S826 | GILSPsELRKI | RhoGEF | PhosphoSitePlus |
| S1239 | IAIPDsHLPVS | PhosphoSitePlus | |
| S1389 | AREAHsDENPS | PhosphoSitePlus | |
| T736 | VTEHGtPKPFR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S818 | FYQRVsREGIL | RhoGEF | PhosphoSitePlus |
| Y1232 | EVGEDyQIAIP | PhosphoSitePlus | |
| T703 | DTLDGtPRTLN | PhosphoSitePlus | |
| Dephosphorylation site |
| ARHGC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000380942 | E1271K | COSMIC | Ovarian Cancer | 20668451 | ENSP00000349056 | M1349I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000380942 | M1368I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000380942 | R647C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000349056 | R210* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000380942 | K927* | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000380942 | E238D | COSMIC | Lung Cancer | 20668451 | ENSP00000380942 | V746A | COSMIC | Breast Cancer | 20668451 | ENSP00000380942 | P875L | COSMIC | Melanoma | 21499247 | ENSP00000380942 | G1398R | COSMIC | Breast Cancer | 20668451 | ENSP00000380942 | E197V | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| ARHGC_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ARHGC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAQ_HUMAN | ARHGC_HUMAN | Gprotein -> effector | gpDB |
| GNA13_HUMAN | ARHGC_HUMAN | Gprotein -> effector | gpDB |
| GNA12_HUMAN | ARHGC_HUMAN | Gprotein -> effector | gpDB |
| ARHG7_HUMAN | ARHGC_HUMAN | other | KEGG |
| GNA13_HUMAN | ARHGC_HUMAN | other | KEGG |
| ARHGC_HUMAN | RHOA_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05152 | Tuberculosis |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04360 | Axon guidance |
| hsa04270 | Vascular smooth muscle contraction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0001664 | G-protein coupled receptor binding | IDA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |