Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BMPR2_HUMAN
Description:bone morphogenetic protein receptor, type II (serine/threonine kinase) [Source:HGNC Symbol;Acc:1078]
Location:chr2 q33.1
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T805HVVTVtMNGVAPhosphoSitePlus
S681NLKESsDENLMPhosphoSitePlus; HPRD
T977KKRVKtPYSLKPhosphoSitePlus
S375DNAAIsEVGTIPkinasePhosphoSitePlus
T575HSMSStPLTIGPhosphoSitePlus
S862RLNINsSPDEHPhosphoSitePlus; HPRD
S515RNKSVsPTVNPPhosphoSitePlus
Y979RVKTPySLKRWPhosphoSitePlus
Y551YSSSSyIEDSIPhosphoSitePlus
Y546GPYPDySSSSYPhosphoSitePlus
S1030ATTMVsKDIGMHPRD
T803EPHVVtVTMNGPhosphoSitePlus
S547PYPDYsSSSYIPhosphoSitePlus
S1011NRAVHsKSSTAHPRD
Y708SSSLLyPLIKLPhosphoSitePlus
S574EHSMSsTPLTIPhosphoSitePlus
S863LNINSsPDEHEPhosphoSitePlus; HPRD; SysPTM
S757PKRPTsLPLNTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S680KNLKEsSDENLPhosphoSitePlus; HPRD
Y589RNSINyERQQAPhosphoSitePlus
S550DYSSSsYIEDSPhosphoSitePlus
Y825AATTQyANGTVPhosphoSitePlus
T379ISEVGtIRYMAPkinasePhosphoSitePlus
S586EKNRNsINYERPhosphoSitePlus; HPRD; SysPTM
S513WERNKsVSPTVHPRD

Dephosphorylation site
BMPR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363708L203VBIOMARTBreast Cancer21930507, 21930502
ENSP00000363708P283TTCGAOvarian Cancer21720365, 18772890
ENSP00000363708L884PTCGAOvarian Cancer21720365, 18772890
ENSP00000363708R974PTCGAOvarian Cancer21720365, 18772890
ENSP00000363708S863TBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
BMPR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BMPR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDF9_HUMANBMPR2_HUMANligand -> receptorHPMR
BMP4_HUMANBMPR2_HUMANligand -> receptorHPMR
BMP15_HUMANBMPR2_HUMANligand -> receptorHPMR
BMP2_HUMANBMPR2_HUMANligand -> receptorHPMR
BMPR2_HUMANRAGE_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
BMPR2_HUMANNLK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060836lymphatic endothelial cell differentiationIEAbiological_process
GO:0060840artery developmentIEAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0009267cellular response to starvationIEPbiological_process
GO:0061298retina vasculature development in camera-type eyeIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:0048010vascular endothelial growth factor receptor signalISSbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0014916regulation of lung blood pressureISSbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIMPbiological_process
GO:0010634positive regulation of epithelial cell migrationIDAbiological_process
GO:0060836lymphatic endothelial cell differentiationISSbiological_process
GO:0048286lung alveolus developmentISSbiological_process
GO:0004675transmembrane receptor protein serine/threonine kiIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016362activin receptor activity, type IITASmolecular_function
GO:0009952anterior/posterior pattern specificationISSbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0001974blood vessel remodelingISSbiological_process
GO:0001707mesoderm formationISSbiological_process
GO:0006366transcription from RNA polymerase II promoterIMPbiological_process
GO:0042127regulation of cell proliferationIMPbiological_process
GO:0030501positive regulation of bone mineralizationIMPbiological_process
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:2000279negative regulation of DNA biosynthetic processIMPbiological_process
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0045906negative regulation of vasoconstrictionIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0060840artery developmentISSbiological_process
GO:0061298retina vasculature development in camera-type eyeISSbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0014916regulation of lung blood pressureIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005901caveolaIMPcellular_component
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0045906negative regulation of vasoconstrictionISSbiological_process
GO:0007178transmembrane receptor protein serine/threonine kiIDAbiological_process
GO:0030513positive regulation of BMP signaling pathwayIMPbiological_process
GO:0030509BMP signaling pathwayISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0060841venous blood vessel developmentIEAbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0060841venous blood vessel developmentISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001946lymphangiogenesisISSbiological_process
GO:0001946lymphangiogenesisIEAbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0003085negative regulation of systemic arterial blood preIMPbiological_process
GO:0009986cell surfaceIEAcellular_component