| UniProt/SwissProt ID: | ARHG1_HUMAN |
| Description: | Rho guanine nucleotide exchange factor (GEF) 1 [Source:HGNC Symbol;Acc:681] |
| Location: | chr19 q13.2 |
| Node attribute: | effector; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S743 | PKPRPsPSSTR | HPRD | |
| S863 | GGGPLsPARTQ | PhosphoSitePlus; HPRD; phosphoELM | |
| S25 | ARGAAsPGPSR | HPRD | |
| S29 | ASPGPsRPGLV | HPRD | |
| S798 | GGRETsPADAR | PhosphoSitePlus; HPRD | |
| S878 | GGGPLsPARTQ | HPRD | |
| Y487 | RQESGyLIEEI | RhoGEF | PhosphoSitePlus |
| S10 | ARGAAsPGPSR | PhosphoSitePlus; HPRD; phosphoELM | |
| S14 | ASPGPsRPGLV | HPRD; phosphoELM | |
| S788 | PLLSSsENGNG | PhosphoSitePlus | |
| T695 | HSRTLtPTPDG | PhosphoSitePlus | |
| S240 | SGDKKsGRNFF | PhosphoSitePlus | |
| S830 | GGGPLsPARTQ | HPRD | |
| S776 | PKPRPsPSSTR | HPRD | |
| S631 | HLRQSsDPMLS | PhosphoSitePlus | |
| S786 | REPLLsSSENG | PhosphoSitePlus | |
| S813 | GGRETsPADAR | HPRD | |
| S765 | GGRETsPADAR | HPRD | |
| S791 | PKPRPsPSSTR | HPRD | |
| Y738 | QEAQIyELVAQ | PhosphoSitePlus | |
| Dephosphorylation site |
| ARHG1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000346532 | M165V | HPI | Colorectal Cancer | 16959974 | ENSP00000337261 | V452M | COSMIC | Skin Cancer | 21984974 | ENSP00000337261 | S3T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000337261 | V165M | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000337261 | A76T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000337261 | R247Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000346532 | Small cell lung carcinoma | Treatment (none vs. isogenic Doxorubicin-resistant) | cell line | Down | 0.38 | 18654985 |
| Hyperphosphorylation site |
| ARHG1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNA12_HUMAN | ARHG1_HUMAN | Gprotein -> effector | gpDB |
| GNA13_HUMAN | ARHG1_HUMAN | Gprotein -> effector | gpDB |
| GNAQ_HUMAN | ARHG1_HUMAN | Gprotein -> effector | gpDB |
| KPCA_HUMAN | ARHG1_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04270 | Vascular smooth muscle contraction |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0050771 | negative regulation of axonogenesis | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0050770 | regulation of axonogenesis | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |