Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRH_HUMAN
Description:thyrotropin-releasing hormone [Source:HGNC Symbol;Acc:12298]
Location:chr3 q22.1
Node attribute:ligand; gene

Phosphorylation site
TRH_HUMAN do not have phosphorylation site.

Dephosphorylation site
TRH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303452V148FCOSMICOvarian Cancer21720365
ENSP00000303452V148FTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
TRH_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TRH_HUMANTRFR_HUMANligand -> receptorHPMR
STAT3_HUMANTRH_HUMANTF -> target geneTRANSFAC
CREB1_HUMANTRH_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TRH_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008437thyrotropin-releasing hormone activityIEAmolecular_function
GO:0007628adult walking behaviorIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030141secretory granuleIEAcellular_component
GO:0014054positive regulation of gamma-aminobutyric acid secIEAbiological_process
GO:0005184neuropeptide hormone activityIEAmolecular_function
GO:0045471response to ethanolIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0001666response to hypoxiaIEAbiological_process
GO:0009409response to coldIEAbiological_process
GO:0042755eating behaviorIEAbiological_process
GO:0014050negative regulation of glutamate secretionIEAbiological_process


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