Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DYR1A_HUMAN
Description:dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A [Source:HGNC Symbol;Acc:3091]
Location:chr21 q22.13
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y319LGQRIyQYIQSPkinasePhosphoSitePlus
Y321QRIYQyIQSRFPkinasePhosphoSitePlus; SysPTM
Y147DDNYDyIVKNGPhosphoSitePlus; HPRD
Y145YDDDNyDYIVKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T751EESPMtGVCVQHPRD
S324YQYIQsRFYRSPkinasePhosphoSitePlus
Y310LGQRIyQYIQSHPRD
Y136YDDDNyDYIVKHPRD
Y319LGQRIyQYIQSautocatalysis RegPhos
S758VCVQQsPVASSPhosphoSitePlus
S529SGRARsDPTHQPhosphoSitePlus; HPRD
Y319LGQRIyQYIQSHPRD; phosphoELM; RegPhos
S706NLTVYsNPRQEPhosphoSitePlus
S519SSGGSsGTSNSDYRK1AHPRD; RegPhos
Y138DDNYDyIVKNGHPRD
Y321QRIYQyIQSRFautocatalysisRegPhos; SysPTM
Y159KWMDRyEIDSLPkinasePhosphoSitePlus
S555DCETHsPQVRQPhosphoSitePlus
Y321QRIYQyIQSRFHPRD; phosphoELM; RegPhos; SysPTM
Y312QRIYQyIQSRFHPRD
Y136KERKVyNDGYDPhosphoSitePlus; HPRD
S520SGRARsDPTHQDYRK1AHPRD
Y705VNLTVySNPRQPhosphoSitePlus
S749VCVQQsPVAHPRD
S529SGRARsDPTHQDYRK1ARegPhos
Y112INEVYyAKKKRPhosphoSitePlus
S748ADREEsPMTGVPhosphoSitePlus; HPRD
Y131VYNDGyDDDNYHPRD
Y140VYNDGyDDDNYHPRD
S758VCVQQsPVAHPRD
Y111HINEVyYAKKKPhosphoSitePlus
Y219DTEMKyYIVHLautocatalysis RegPhos
S538HQHRHsGGHFTPhosphoSitePlus
Y127KERKVyNDGYDHPRD
S739ADREEsPMTGVHPRD
T742EESPMtGVCVQHPRD

Dephosphorylation site
DYR1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381932I283VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
DYR1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DYR1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYR1A_HUMANDYN1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANDYR1A_HUMANkinase -> substrateRegPhos
DYR1A_HUMANDYR1A_HUMANkinase -> substrateRegPhos
DYR1A_HUMANSF3B1_HUMANkinase -> substrateHPRD; RegPhos
DYR1A_HUMANFOXO1_HUMANkinase -> substrateRegPhos
DYR1A_HUMANCCNL2_HUMANkinase -> substrateRegPhos
DYR1A_HUMANCREB1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
DYR1A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0004712protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0048156tau protein bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006468protein phosphorylationISSbiological_process
GO:0043621protein self-associationIEAmolecular_function
GO:0043518negative regulation of DNA damage response, signalIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0090312positive regulation of protein deacetylationIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005634nucleusISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016607nuclear speckIEAcellular_component


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