Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CRF_HUMAN
Description:corticotropin releasing hormone [Source:HGNC Symbol;Acc:2355]
Location:chr8 q13.1
Node attribute:ligand; gene

Phosphorylation site
CRF_HUMAN do not have phosphorylation site.

Dephosphorylation site
CRF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000276571E134QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CRF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CRF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CRF_HUMANCRFR1_HUMANligand -> receptorHPMR
CRF_HUMANCRFR2_HUMANligand -> receptorHPMR
CREB1_HUMANCRF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05034Alcoholism
hsa04730Long-term depression

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000854positive regulation of corticosterone secretionIEAbiological_process
GO:0006954inflammatory responseIDAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0016101diterpenoid metabolic processIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0017045corticotropin-releasing hormone activityIEAmolecular_function
GO:0006954inflammatory responseIEAbiological_process
GO:0035902response to immobilization stressIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:0032811negative regulation of epinephrine secretionIEAbiological_process
GO:0042322negative regulation of circadian sleep/wake cycle,NASbiological_process
GO:0035641locomotory exploration behaviorIEAbiological_process
GO:2000310regulation of N-methyl-D-aspartate selective glutaIEAbiological_process
GO:0043204perikaryonIEAcellular_component
GO:0033685negative regulation of luteinizing hormone secretiIEAbiological_process
GO:0010700negative regulation of norepinephrine secretionIEAbiological_process
GO:0050801ion homeostasisIEAbiological_process
GO:0051461positive regulation of corticotropin secretionIEAbiological_process
GO:2000987positive regulation of behavioral fear responseIEAbiological_process
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0005184neuropeptide hormone activityTASmolecular_function
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIEAbiological_process
GO:0051430corticotropin-releasing hormone receptor 1 bindingIEAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0008306associative learningIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0045472response to etherIEAbiological_process
GO:0007565female pregnancyIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0043196varicosityIEAcellular_component
GO:0010942positive regulation of cell deathIEAbiological_process
GO:0021854hypothalamus developmentIEAbiological_process
GO:0006704glucocorticoid biosynthetic processIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0035774positive regulation of insulin secretion involved IEAbiological_process
GO:2000310regulation of N-methyl-D-aspartate selective glutaIDAbiological_process
GO:0007631feeding behaviorIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0008202steroid metabolic processIEAbiological_process
GO:0071314cellular response to cocaineIEAbiological_process
GO:0014062regulation of serotonin secretionIEAbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0010841positive regulation of circadian sleep/wake cycle,NASbiological_process
GO:0071549cellular response to dexamethasone stimulusIEAbiological_process
GO:0033494ferulate metabolic processIEAbiological_process
GO:0001963synaptic transmission, dopaminergicIDAbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007611learning or memoryTASbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048265response to painIEAbiological_process
GO:0070093negative regulation of glucagon secretionIEAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0060548negative regulation of cell deathIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0051431corticotropin-releasing hormone receptor 2 bindingIEAmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0005179hormone activityTASmolecular_function
GO:0043025neuronal cell bodyIEAcellular_component
GO:0007567parturitionTASbiological_process
GO:0090280positive regulation of calcium ion importIEAbiological_process
GO:0060456positive regulation of digestive system processIEAbiological_process
GO:0051464positive regulation of cortisol secretionIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0008628hormone-mediated apoptotic signaling pathwayIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process