Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MARK2_HUMAN
Description:MAP/microtubule affinity-regulating kinase 2 [Source:HGNC Symbol;Acc:3332]
Location:chr11 q13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S705RFKRIsGTSMAHPRD
S10RNSATsADEQPHPRD
S566TPASPsGHSQGHPRD
S357NSSAPsPSHKVHPRD
T465LERKKtTPTPSHPRD
S30DSKPSsKSNMIPhosphoSitePlus
S578HNISSsGGAPDPhosphoSitePlus
S197ADFGFsNEFTFPkinasePhosphoSitePlus
T467ERKKTtPTPSTPhosphoSitePlus
S365LLGYKsSELEGPhosphoSitePlus
S40IRGRNsATSADPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S212DTFCGsPPYAAHPRD; RegPhos
S516PVASPsAHNISHPRD
T438TPTPStNSVLSHPRD
T596VSSRStFHAGQPKC_alphaphosphoELM
T175GNKLDtFCGSPHPRD
S455AKVPAsPLPGLHPRD
S595GVSSRsTFHAGPhosphoSitePlus; phosphoELM
S43RNSATsADEQPPhosphoSitePlus; HPRD; phosphoELM
T6LPTLHPRD
S7TSADHPRD
S449TSTNRsRNSPLHPRD
T432LERKKtTPTPSHPRD
T596VSSRStFHAGQPKCa(PKC alphaRegPhos
S621TPASPsGHSQGPhosphoSitePlus; HPRD; phosphoELM
S437TTPTPsTNSVLHPRD
S26LGHLDsKPSSKPhosphoSitePlus
S409KQRRFsDQAAGPhosphoSitePlus; HPRD; phosphoELM
T667KDRVEtLRPHVPhosphoSitePlus; HPRD
T9GRNSAtSADEQHPRD
S179DTFCGsPPYAAHPRD
S521SAHNIsSSGGAHPRD
S569SPSGHsQGRRGHPRD
Y558QQNLPyGVTPAHPRD
S593PRGVSsRSTFHPhosphoSitePlus
S376KQRRFsDQAGPHPRD
S493LLERAsLGQASPhosphoSitePlus; HPRD
S400VQRSVsANPKQPhosphoSitePlus
T87KIIDKtQLNSSPkinasePhosphoSitePlus
S769RFKRIsGTSMAHPRD
T624KDRVEtLRPHVHPRD
S535RVPVAsPSAHNHPRD
Y613QQNLPyGVTPAPhosphoSitePlus; HPRD
T616LPYGVtPASPSPhosphoSitePlus
S456AKVPAsPLPGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y351LVGQRyNEVMAUBAPhosphoSitePlus
S587TPASPsGHSQGHPRD
T562VSSRStFHAGQHPRD
S485NRSRNsPLLERHPRD
T351PSADLtNSSAPHPRD
T471TPTPStNSVLSHPRD
S533RQHQKsMSASVPhosphoSitePlus
T20DTEQPtLGHLDPhosphoSitePlus
T208GNKLDtFCGSPLKB1phosphoELM
S726RFKRIsGTSMAHPRD
T58YRLLKtIGKGNPkinasePhosphoSitePlus
S698LRFTWsMKTTSPhosphoSitePlus
S483TSTNRsRNSPLPhosphoSitePlus; HPRD
T419GPAIPtSNSYSHPRD
S564GVTPAsPSGHSHPRD
Y323EPLPDyKDPRRPhosphoSitePlus
S498SLGQAsIQNGKPhosphoSitePlus
T201FSNEFtFGNKLPkinasePhosphoSitePlus
T208GNKLDtFCGSPHPRD; phosphoELM; RegPhos
T208GNKLDtFCGSPPkinasePhosphoSitePlus
S452NRSRNsPLLERHPRD
S479SVLSTsTNRSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T472TPTPStNSVLSPhosphoSitePlus; HPRD
S477TNSVLsTSTNRPhosphoSitePlus
S722VLDANsCQSELPhosphoSitePlus
S445SVLSTsTNRSRHPRD
S486NRSRNsPLLERPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S619GVTPAsPSGHSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S422IPTSNsYSKKTPhosphoSitePlus; RegPhos
S470TTPTPsTNSVLHPRD
S212DTFCGsPPYAAPkinasePhosphoSitePlus
S290LILNPsKRGTLPkinasePhosphoSitePlus
S390NSSAPsPSHKVPhosphoSitePlus; HPRD
Y579QQNLPyGVTPAHPRD
S648VRRNLsFRFARPhosphoSitePlus
S29LDSKPsSKSNMPhosphoSitePlus
S675PHVVGsGGNDKPhosphoSitePlus
S514RVPVAsPSAHNHPRD
S542SAHNIsSSGGAHPRD
T596VSSRStFHAGQPKCzRegPhos
T596VSSRStFHAGQPhosphoSitePlus; HPRD; RegPhos
S592FPRGVsSRSTFPhosphoSitePlus
T208GNKLDtFCGSPLKB1(STK11RegPhos
S422AKVPAsPLPGLHPRD
S471TTPTPsTNSVLPhosphoSitePlus; HPRD
S492LLERAsLGQASHPRD
S631GRRGAsGSIFSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S571PVASPsAHNISPhosphoSitePlus; phosphoELM; RegPhos
S692EAKPRsLRFTWPhosphoSitePlus
S624SPSGHsQGRRGPhosphoSitePlus; HPRD; phosphoELM
Y358EVMATyLLLGYUBAPhosphoSitePlus
T541VSSRStFHAGQHPRD
S597GRRGAsGSIFSHPRD
T42GRNSAtSADEQPhosphoSitePlus; HPRD; phosphoELM
S478SVLSTsTNRSRHPRD
S576GRRGAsGSIFSHPRD
S590SPSGHsQGRRGHPRD
S576SAHNIsSSGGAPhosphoSitePlus; HPRD; phosphoELM
Y363YLLLGyKSSELPhosphoSitePlus
T603KDRVEtLRPHVHPRD
T384PSADLtNSSAPHPRD
S569RVPVAsPSAHNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T469KKTTPtPSTNSPhosphoSitePlus; phosphoELM; RegPhos
T466LERKKtTPTPSPhosphoSitePlus; HPRD
S585GVTPAsPSGHSHPRD
S482TSTNRsRNSPLHPRD
S409KQRRFsDQAGPHPRD
S459LLERAsLGQASHPRD

Dephosphorylation site
MARK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367041D160EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000367040D175EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000385751D175EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000386128D160EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000423974D160EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000294247D193EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000425765D193EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000326632D175EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000355091D175EBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000385751Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
MARK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MARK2_HUMANCAH5B_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANZN565_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANDVL3_HUMANkinase -> substrateNetPath
MARK2_HUMANZN746_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANWIPI3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMARK2_HUMANkinase -> substrateRegPhos
MARK2_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANMARK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANMARK2_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANZN213_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MARK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0006979response to oxidative stressIEPbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0010976positive regulation of neuron projection developmeIDAbiological_process
GO:0051493regulation of cytoskeleton organizationIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0050770regulation of axonogenesisIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0045180basal cortexIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0050321tau-protein kinase activityIEAmolecular_function
GO:0045197establishment or maintenance of epithelial cell apIDAbiological_process
GO:0030010establishment of cell polarityIDAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process


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