| UniProt/SwissProt ID: | CCNA2_HUMAN |
| Description: | cyclin A2 [Source:HGNC Symbol;Acc:1578] |
| Location: | chr4 q27 |
| Node attribute: | kinase; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S5 | PGPA | HPRD | |
| S5 | _MLGNsAPGPA | PhosphoSitePlus | |
| Y146 | LVPLDyPMDGS | HPRD | |
| S244 | IDRFLsSMSVL | Cyclin_N | PhosphoSitePlus |
| S151 | YPMDGsFESPH | HPRD | |
| S209 | PDITNsMRAIL | Cyclin_N | PhosphoSitePlus |
| S154 | DGSFEsPHTMD | PhosphoSitePlus | |
| S55 | LAVLKsGNPRG | PhosphoSitePlus | |
| Dephosphorylation site |
| CCNA2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000274026 | M160I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000274026 | I162L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000274026 | V219F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| CCNA2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CCNA2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CCNA2_HUMAN | BTG1_HUMAN | kinase -> substrate | HPRD |
| CREB1_HUMAN | CCNA2_HUMAN | TF -> target gene | TRANSFAC |
| ATF2_HUMAN | CCNA2_HUMAN | TF -> target gene | TRANSFAC |
| NFYA_HUMAN | CCNA2_HUMAN | TF -> target gene | TRANSFAC |
| CREM_HUMAN | CCNA2_HUMAN | TF -> target gene | TRANSFAC |
| ATF1_HUMAN | CCNA2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa05203 | Viral carcinogenesis |
| hsa05169 | Epstein-Barr virus infection |
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007095 | mitotic cell cycle G2/M transition DNA damage chec | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0001940 | male pronucleus | IEA | cellular_component |
| GO:0001939 | female pronucleus | IEA | cellular_component |
| GO:0007265 | Ras protein signal transduction | IEP | biological_process |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |