Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCNA2_HUMAN
Description:cyclin A2 [Source:HGNC Symbol;Acc:1578]
Location:chr4 q27
Node attribute:kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S5PGPAHPRD
S5_MLGNsAPGPAPhosphoSitePlus
Y146LVPLDyPMDGSHPRD
S244IDRFLsSMSVLCyclin_NPhosphoSitePlus
S151YPMDGsFESPHHPRD
S209PDITNsMRAILCyclin_NPhosphoSitePlus
S154DGSFEsPHTMDPhosphoSitePlus
S55LAVLKsGNPRGPhosphoSitePlus

Dephosphorylation site
CCNA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000274026M160IBIOMARTBreast Cancer21930507, 21930502
ENSP00000274026I162LCOSMICOvarian Cancer21720365
ENSP00000274026V219FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CCNA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCNA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCNA2_HUMANBTG1_HUMANkinase -> substrateHPRD
CREB1_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
NFYA_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
CREM_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
ATF1_HUMANCCNA2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa05203Viral carcinogenesis
hsa05169Epstein-Barr virus infection
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007095mitotic cell cycle G2/M transition DNA damage checTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0001940male pronucleusIEAcellular_component
GO:0001939female pronucleusIEAcellular_component
GO:0007265Ras protein signal transductionIEPbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0051301cell divisionIEAbiological_process


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