Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BDNF_HUMAN
Description:brain-derived neurotrophic factor [Source:HGNC Symbol;Acc:1033]
Location:chr11 p14.1
Node attribute:PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T155AADKKtAVDMSNGFPhosphoSitePlus
Y116EEYKNyLDAANPhosphoSitePlus
Y191CNPMGyTKEGCNGFPhosphoSitePlus

Dephosphorylation site
BDNF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000435564*248KCOSMICHead and Neck Cancer21798893
ENSP00000389345E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432727*248KCOSMICHead and Neck Cancer21798893
ENSP00000379302E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000389345*248KCOSMICHead and Neck Cancer21798893
ENSP00000432035E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432376*248KCOSMICHead and Neck Cancer21798893
ENSP00000389564E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000379304*248KCOSMICHead and Neck Cancer21798893
ENSP00000435805E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000379302*248KCOSMICHead and Neck Cancer21798893
ENSP00000379304E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000435564E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000437138*248KCOSMICHead and Neck Cancer21798893
ENSP00000435805*248KCOSMICHead and Neck Cancer21798893
ENSP00000379305*248KCOSMICHead and Neck Cancer21798893
ENSP00000400502*248KCOSMICHead and Neck Cancer21798893
ENSP00000379307E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432035*248KCOSMICHead and Neck Cancer21798893
ENSP00000379305E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000349084E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000437138E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432727E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000349084*248KCOSMICHead and Neck Cancer21798893
ENSP00000379309E83QBIOMARTBreast Cancer21930507, 21930502
ENSP00000320002E76QBIOMARTBreast Cancer21930507, 21930502
ENSP00000389564*248KCOSMICHead and Neck Cancer21798893
ENSP00000414303E150QBIOMARTBreast Cancer21930507, 21930502
ENSP00000379307*248KCOSMICHead and Neck Cancer21798893
ENSP00000400502E68QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432376E68QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
BDNF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BDNF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BDNF_HUMANNTRK1_HUMANotherKEGG
CREB1_HUMANBDNF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05030Cocaine addiction
hsa05034Alcoholism
hsa05016Huntington's disease
hsa04722Neurotrophin signaling pathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014076response to fluoxetineIEAbiological_process
GO:0048471perinuclear region of cytoplasmISScellular_component
GO:0014047glutamate secretionIEAbiological_process
GO:0016358dendrite developmentIEAbiological_process
GO:0006120mitochondrial electron transport, NADH to ubiquinoIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0042490mechanoreceptor differentiationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0042596fear responseIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008038neuron recognitionIEAbiological_process
GO:0048170positive regulation of long-term neuronal synapticIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0002544chronic inflammatory responseIEAbiological_process
GO:0008021synaptic vesicleIEAcellular_component
GO:0043523regulation of neuron apoptotic processIEAbiological_process
GO:0007406negative regulation of neuroblast proliferationIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0021675nerve developmentIEAbiological_process
GO:0005169neurotrophin TRKB receptor bindingIEAmolecular_function
GO:0009725response to hormone stimulusIEAbiological_process
GO:0007631feeding behaviorIEAbiological_process
GO:0048172regulation of short-term neuronal synaptic plasticIEAbiological_process
GO:0045843negative regulation of striated muscle tissue deveIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0051965positive regulation of synapse assemblyIDAbiological_process
GO:0046668regulation of retinal cell programmed cell deathIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0050890cognitionIEAbiological_process
GO:0055093response to hyperoxiaIEAbiological_process
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0033189response to vitamin AIEAbiological_process
GO:0007412axon target recognitionIEAbiological_process
GO:0007610behaviorIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0072347response to anestheticIEAbiological_process
GO:0019222regulation of metabolic processIEAbiological_process
GO:0031667response to nutrient levelsIEAbiological_process
GO:0005737cytoplasmISScellular_component