Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CFTR_HUMAN
Description:cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) [Source:HGNC Symbol;Acc:1884]
Location:chr7 q31.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S660AERRNsILTETCFTR_RPhosphoSitePlus
S700EKRKNsILNPIPRKG1HPRD
S1362ARSVLsKAKILHPRD
S712SIRKFsIVQKTphosphoELM; RegPhos
S686ETKKQsFKQTGPKCa(PKC alphaRegPhos
S813YSRRLsQETGLPKG_groupRegPhos
S686ETKKQsFKQTGCFTR_RPhosphoSitePlus
S768ARRRQsVLNLMPKACaRegPhos
S795STRKVsLAPQAPRKACAHPRD
S737LERRLsLVPDSPRKACAHPRD
S795STRKVsLAPQAPKACaRegPhos
T1019YIFVAtVPVIVTM; ABC_membranePhosphoSitePlus
Y515VSYDEyRYRSVABC_tranPhosphoSitePlus
S422NNRKTsNGDDSRotamase_2PhosphoSitePlus
S768ARRRQsVLNLMPKG/cGK_groupphosphoELM
S768ARRRQsVLNLMPRKG1HPRD
S795STRKVsLAPQAPKG/cGK_groupphosphoELM
T291ENLRQtELKLTHPRD
S753ILPRIsVISTGPKA_groupphosphoELM; RegPhos
S790RKTTAsTRKVSPRKCAHPRD
S768ARRRQsVLNLMPKG_groupRegPhos
S768ARRRQsVLNLMPKA_groupphosphoELM; RegPhos
S737LERRLsLVPDSPKG_groupRegPhos
S686ETKKQsFKQTGPRKCAHPRD
S795STRKVsLAPQAPKG_groupRegPhos
S660AERRNsILTETPKG1RegPhos
S660AERRNsILTETPRKG1HPRD
S686ETKKQsFKQTGPKCaRegPhos
S700EKRKNsILNPIPKG_groupRegPhos
S795STRKVsLAPQACFTR_RPhosphoSitePlus
S813YSRRLsQETGLPKA_groupphosphoELM; RegPhos
Y1014AVLQPyIFVATTM; ABC_membranePhosphoSitePlus
T682VSWTEtKKQSFCFTR_RPhosphoSitePlus
S700EKRKNsILNPIPKG/cGK_groupphosphoELM
S641LQPDFsSKLMGCFTR_RPhosphoSitePlus
S707LNPINsIRKFSCFTR_RPhosphoSitePlus
S686ETKKQsFKQTGPKC_alphaphosphoELM
S813YSRRLsQETGLPKG/cGK_groupphosphoELM
S790RKTTAsTRKVSCFTR_RPhosphoSitePlus
Y512IFGVSyDEYRYABC_tranPhosphoSitePlus
T291ENLRQtELKLTABC_membranePhosphoSitePlus
S737LERRLsLVPDSPRKG1HPRD
S813YSRRLsQETGLPKG1RegPhos
T582YLDVLtEKEIFPhosphoSitePlus
S700EKRKNsILNPIPKG1RegPhos
T604TRILVtSKMEHPhosphoSitePlus
S712SIRKFsIVQKTCFTR_RPhosphoSitePlus
S768ARRRQsVLNLMCFTR_RPhosphoSitePlus
S813YSRRLsQETGLCFTR_RPhosphoSitePlus
S605RILVTsKMEHLPhosphoSitePlus
T1176TEGKPtKSTKPHPRD
S790RKTTAsTRKVSPKC_groupphosphoELM; RegPhos
S700EKRKNsILNPICFTR_RPhosphoSitePlus
S712SIRKFsIVQKTPKA_groupRegPhos
S776NLMTHsVNQGQCFTR_RPhosphoSitePlus
S813YSRRLsQETGLPKACaRegPhos
S660AERRNsILTETPKG/cGK_groupphosphoELM
S768ARRRQsVLNLMPKG1RegPhos
S737LERRLsLVPDSPKG/cGK_groupphosphoELM
S700EKRKNsILNPIPRKACAHPRD
S686ETKKQsFKQTGPKC_groupphosphoELM; RegPhos
S700EKRKNsILNPIPKACaRegPhos
S549GGITLsGGQRAHPRD
S549GGITLsGGQRAABC_tranPhosphoSitePlus
S813YSRRLsQETGLPRKACAHPRD
S737LERRLsLVPDSCFTR_RPhosphoSitePlus
S753ILPRIsVISTGCFTR_RPhosphoSitePlus
S700EKRKNsILNPIPKA_groupphosphoELM; RegPhos
S1362ARSVLsKAKILABC_tranPhosphoSitePlus
S768ARRRQsVLNLMPRKACAHPRD
S660AERRNsILTETPKG_groupRegPhos
S813YSRRLsQETGLPRKG1HPRD
S737LERRLsLVPDSPKACaRegPhos
S511IIFGVsYDEYRABC_tranPhosphoSitePlus
S795STRKVsLAPQAPKA_groupphosphoELM; RegPhos
S256RAGKIsERLVIABC_membranePhosphoSitePlus
T774VLNLMtHSVNQCFTR_RPhosphoSitePlus
S795STRKVsLAPQAPKG1RegPhos
S795STRKVsLAPQAPRKG1HPRD
Y1424NKVRQyDSIQKPhosphoSitePlus
S809ELDIYsRRLSQCFTR_RPhosphoSitePlus
S737LERRLsLVPDSPKG1RegPhos
S737LERRLsLVPDSPKA_groupphosphoELM; RegPhos
S790RKTTAsTRKVSPKCaRegPhos
T1471ALKEEtEEEVQPhosphoSitePlus
S660AERRNsILTETPKA_groupphosphoELM; RegPhos

Dephosphorylation site
CFTR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000003084Q1071*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000003084S1248LCOSMICMelanoma21499247
ENSP00000003084P355SCOSMICMelanoma21499247
ENSP00000403677F855IBIOMARTBreast Cancer21930507, 21930502
ENSP00000003084F916IBIOMARTBreast Cancer21930507, 21930502
ENSP00000003084S108YTCGAOvarian Cancer21720365, 18772890
ENSP00000003084Q414KBIOMARTBreast Cancer21930507, 21930502
ENSP00000003084P205SCOSMICSkin Cancer21984974
ENSP00000003084N386KCOSMICOvarian Cancer21720365
ENSP00000403677Q1010*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000003084E608KCOSMICSkin Cancer21984974
ENSP00000003084S108YCOSMICOvarian Cancer21720365

Differential expressed protein
CFTR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CFTR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANCFTR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANCFTR_HUMANkinase -> substrateRegPhos
KGP1_HUMANCFTR_HUMANkinase -> substrateHPRD
CEBPD_HUMANCFTR_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCFTR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04971Gastric acid secretion
hsa05110Vibrio cholerae infection
hsa02010ABC transporters
hsa04972Pancreatic secretion
hsa04976Bile secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0042626ATPase activity, coupled to transmembrane movementIEAmolecular_function
GO:0032870cellular response to hormone stimulusIEAbiological_process
GO:0005254chloride channel activityIDAmolecular_function
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006810transportTASbiological_process
GO:0019869chloride channel inhibitor activityIDAmolecular_function
GO:0016887ATPase activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0030321transepithelial chloride transportIEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0015705iodide transportIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0006821chloride transportIEAbiological_process
GO:0005260channel-conductance-controlling ATPase activityNASmolecular_function
GO:0005769early endosomeIDAcellular_component
GO:0031901early endosome membraneIEAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0042311vasodilationIEAbiological_process
GO:0006811ion transportIEAbiological_process
GO:0031205endoplasmic reticulum Sec complexIDAcellular_component
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0015701bicarbonate transportIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0030301cholesterol transportIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0045909positive regulation of vasodilationIEAbiological_process
GO:0005224ATP-binding and phosphorylation-dependent chlorideTASmolecular_function
GO:0034707chloride channel complexIEAcellular_component
GO:0005902microvillusIEAcellular_component
GO:0007585respiratory gaseous exchangeTASbiological_process
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0006695cholesterol biosynthetic processIEAbiological_process
GO:0030659cytoplasmic vesicle membraneIEAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0006833water transportIEAbiological_process
GO:0005737cytoplasmIEAcellular_component