Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TPA_HUMAN
Description:plasminogen activator, tissue [Source:HGNC Symbol;Acc:9051]
Location:chr8 p11.21
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T477PSSRCtSQHLLTrypsinPhosphoSitePlus
S474RLYPSsRCTSQTrypsinPhosphoSitePlus
S473VRLYPsSRCTSTrypsinPhosphoSitePlus
S478SSRCTsQHLLNTrypsinPhosphoSitePlus

Dephosphorylation site
TPA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000392045G337ECOSMICMelanoma
ENSP00000220809G337ECOSMICMelanoma

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000220809Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.6515169874

Hyperphosphorylation site
TPA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPA_HUMANLRP1_HUMANligand -> receptorHPMR
ATF2_HUMANTPA_HUMANTF -> target geneTRANSFAC
CREB1_HUMANTPA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014909smooth muscle cell migrationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006464cellular protein modification processTASbiological_process
GO:0060279positive regulation of ovulationIEAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0045202synapseIEAcellular_component
GO:0031639plasminogen activationIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0004252serine-type endopeptidase activityIEAmolecular_function
GO:0051591response to cAMPIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0004252serine-type endopeptidase activityIDAmolecular_function
GO:0045861negative regulation of proteolysisIDAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0042730fibrinolysisTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0030141secretory granuleIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0035249synaptic transmission, glutamatergicIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23