| UniProt/SwissProt ID: | TNI3K_HUMAN |
| Description: | TNNI3 interacting kinase [Source:HGNC Symbol;Acc:19661] |
| Location: | chr1 p31.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y62 | KVNLNyRTENG | PhosphoSitePlus | |
| T805 | RSLQYtPIDKY | Pkinase_Tyr | PhosphoSitePlus |
| Y812 | IDKYGyVSDPM | Pkinase_Tyr | PhosphoSitePlus |
| Y810 | TPIDKyGYVSD | Pkinase_Tyr | PhosphoSitePlus |
| S424 | PGGDGsYVSVP | Ank_2 | PhosphoSitePlus |
| Y425 | GGDGSyVSVPS | Ank_2 | PhosphoSitePlus |
| Y788 | QSAGQySSQGL | Pkinase_Tyr | PhosphoSitePlus |
| S814 | KYGYVsDPMSS | Pkinase_Tyr | PhosphoSitePlus |
| Y771 | RFELEyALNAR | Pkinase_Tyr | PhosphoSitePlus |
| Y804 | KRSLQyTPIDK | Pkinase_Tyr | PhosphoSitePlus |
| S427 | DGSYVsVPSPL | Ank_2 | PhosphoSitePlus |
| Y416 | LPCNEySQPGG | Ank_2 | PhosphoSitePlus |
| Dephosphorylation site |
| TNI3K_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000322251 | G131A | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000322251 | S430L | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000322251 | R629G | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000322251 | R776S | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000322251 | M798I | Greenman2007 | Head and Neck Cancer | 17344846, 18428421 | ENSP00000322251 | R629G | Sjoblom2006 | Intestines Cancer | 16959974 |
| Differential expressed protein |
| TNI3K_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TNI3K_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNI3K_HUMAN | ANXA6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | COF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | FHL2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | NPM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | TAF10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | RMP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | DAXX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | PP1R8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | NFAC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | CCD40_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | MDFI_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | GAS7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | 4ET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | PCM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | PSA6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | RGCC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | BAD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | TRIP6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | PSA7L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | BAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | VHL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | PRD10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | TIF1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | CSDC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TNI3K_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0031013 | troponin I binding | IPI | molecular_function |