| UniProt/SwissProt ID: | ANXA6_HUMAN |
| Description: | annexin A6 [Source:HGNC Symbol;Acc:544] |
| Location: | chr5 q33.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y95 | MRPPAyCDAKE | PhosphoSitePlus | |
| Y609 | FADKLyKSMKG | Annexin | PhosphoSitePlus |
| Y302 | YEKSLySMIKN | Annexin | PhosphoSitePlus |
| Y30 | DAEALyTAMKG | Annexin | PhosphoSitePlus |
| Y572 | IKMTNyDVEHT | Annexin | PhosphoSitePlus |
| T464 | IEILAtRTNAE | Annexin | PhosphoSitePlus |
| S13 | AKYRGsIHDFP | PhosphoSitePlus | |
| S235 | IRGELsGDFEK | Annexin | PhosphoSitePlus |
| S583 | IKKEMsGDVRD | Annexin | PhosphoSitePlus |
| T269 | MKGLGtRDNTL | Annexin | PhosphoSitePlus; SysPTM |
| T381 | MKGLGtDEDTI | HPRD | |
| Y185 | DVQDLyEAGEL | Annexin | PhosphoSitePlus |
| Y76 | IADLKyELTGK | Annexin | PhosphoSitePlus |
| Y313 | DTSGEyKKTLL | Annexin | PhosphoSitePlus |
| T391 | IIDIItHRSNV | HPRD | |
| S303 | EKSLYsMIKND | Annexin | PhosphoSitePlus |
| Y297 | IFRTKyEKSLY | Annexin | PhosphoSitePlus |
| Y30 | DAEALyTAMKG | HPRD; phosphoELM | |
| S251 | VKCIRsTPEYF | HPRD | |
| Y340 | AAQVAyQMWEL | PhosphoSitePlus | |
| S229 | KPIEAsIRGEL | HPRD | |
| S310 | IKNDTsGEYKK | Annexin | PhosphoSitePlus |
| S229 | KPIEAsIRGEL | Annexin | PhosphoSitePlus |
| T356 | VELKGtVRPAN | PhosphoSitePlus | |
| T48 | ILDIItSRSNR | HPRD | |
| Dephosphorylation site |
| ANXA6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000346550 | R231Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000346550 | Breast Cancer | Metastasis | tissue | Down | 18257521 | ENSP00000346550 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.22 | 16097030 | ENSP00000346550 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 17447055 | ENSP00000346550 | Small cell lung carcinoma | Treatment (none vs. isogenic Doxorubicin-resistant) | cell line | Up | 2.4 | 18654985 | ENSP00000346550 | Breast Cancer | Normal vs. Cancer | cell line | Up | 2.3 | 20052998 | ENSP00000346550 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20052998 | ENSP00000346550 | Breast Cancer | Metastasis | cell line | Down | 0.61 | 20052998 | ENSP00000346550 | Breast Cancer | Normal vs. Cancer | tissue | Down | 20560667 | ENSP00000346550 | Breast Cancer | Cancer vs. Cancer (Non-TNBC vs. TNBC) | cell line | Up | 20596302 | ENSP00000346550 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.31 | 16400690 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y95 | GLMRPPAyCDAKEIK | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus | Y302 | Annexin | TKYEKSLySMIKNDT | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus | Y609 | Annexin | LFFADKLyKSMKGAG | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNI3K_HUMAN | ANXA6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ANXA6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005544 | calcium-dependent phospholipid binding | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0006937 | regulation of muscle contraction | IEA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |