Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANXA6_HUMAN
Description:annexin A6 [Source:HGNC Symbol;Acc:544]
Location:chr5 q33.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y95MRPPAyCDAKEPhosphoSitePlus
Y609FADKLyKSMKGAnnexinPhosphoSitePlus
Y302YEKSLySMIKNAnnexinPhosphoSitePlus
Y30DAEALyTAMKGAnnexinPhosphoSitePlus
Y572IKMTNyDVEHTAnnexinPhosphoSitePlus
T464IEILAtRTNAEAnnexinPhosphoSitePlus
S13AKYRGsIHDFPPhosphoSitePlus
S235IRGELsGDFEKAnnexinPhosphoSitePlus
S583IKKEMsGDVRDAnnexinPhosphoSitePlus
T269MKGLGtRDNTLAnnexinPhosphoSitePlus; SysPTM
T381MKGLGtDEDTIHPRD
Y185DVQDLyEAGELAnnexinPhosphoSitePlus
Y76IADLKyELTGKAnnexinPhosphoSitePlus
Y313DTSGEyKKTLLAnnexinPhosphoSitePlus
T391IIDIItHRSNVHPRD
S303EKSLYsMIKNDAnnexinPhosphoSitePlus
Y297IFRTKyEKSLYAnnexinPhosphoSitePlus
Y30DAEALyTAMKGHPRD; phosphoELM
S251VKCIRsTPEYFHPRD
Y340AAQVAyQMWELPhosphoSitePlus
S229KPIEAsIRGELHPRD
S310IKNDTsGEYKKAnnexinPhosphoSitePlus
S229KPIEAsIRGELAnnexinPhosphoSitePlus
T356VELKGtVRPANPhosphoSitePlus
T48ILDIItSRSNRHPRD

Dephosphorylation site
ANXA6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346550R231QCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000346550Breast CancerMetastasistissueDown18257521
ENSP00000346550hepatitis C virusNormal vs. CancertissueDown0.2216097030
ENSP00000346550Hepatocellular CarcinomaNormal vs. CancertissueUp17447055
ENSP00000346550Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineUp2.418654985
ENSP00000346550Breast CancerNormal vs. Cancercell lineUp2.320052998
ENSP00000346550Breast CancerNormal vs. Cancercell lineUp1.420052998
ENSP00000346550Breast CancerMetastasiscell lineDown0.6120052998
ENSP00000346550Breast CancerNormal vs. CancertissueDown20560667
ENSP00000346550Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000346550Esophageal CancerNormal vs. CancertissueDown0.3116400690

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y95GLMRPPAyCDAKEIKcholangiocellular carcinoma21253578PhosphoSitePlus
Y302AnnexinTKYEKSLySMIKNDTcholangiocellular carcinoma21253578PhosphoSitePlus
Y609AnnexinLFFADKLyKSMKGAGcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
TNI3K_HUMANANXA6_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ANXA6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005544calcium-dependent phospholipid bindingIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0006937regulation of muscle contractionIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0006816calcium ion transportIEAbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component


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