Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PSA7L_HUMAN
Description:proteasome (prosome, macropain) subunit, alpha type, 8 [Source:HGNC Symbol;Acc:22985]
Location:chr18 q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T160TDPSGtYHAWKProteasomePhosphoSitePlus
S229PLKMFsAKEVEPhosphoSitePlus
S158YQTDPsGTYHAProteasomePhosphoSitePlus
S13AITVFsPDGHLProteasome_A_NPhosphoSitePlus
Y161DPSGTyHAWKAProteasomePhosphoSitePlus

Dephosphorylation site
PSA7L_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000311121R132QCOSMICSkin Cancer21984974
ENSP00000409284E22KBIOMARTBreast Cancer21930507, 21930502
ENSP00000345584E22KBIOMARTBreast Cancer21930507, 21930502
ENSP00000409284G36EBIOMARTMelanoma21930507, 21930502
ENSP00000311121E22KBIOMARTBreast Cancer21930507, 21930502
ENSP00000311121G36ECOSMICMelanoma20016485

Differential expressed protein
PSA7L_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PSA7L_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK3_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PSA7L_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0004298threonine-type endopeptidase activityIEAmolecular_function
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0004175endopeptidase activityIEAmolecular_function
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0006521regulation of cellular amino acid metabolic procesTASbiological_process
GO:0019773proteasome core complex, alpha-subunit complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0051603proteolysis involved in cellular protein catabolicIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0005839proteasome core complexIEAcellular_component
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process


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