Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PI3R5_HUMAN
Description:phosphoinositide-3-kinase, regulatory subunit 5 [Source:HGNC Symbol;Acc:30035]
Location:chr17 p13.1
Node attribute:PPI(source); Enzyme(source); Enzyme(target); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T114YHRFLtWPVPYPI3K_1B_p101PhosphoSitePlus
S507RRPFLsGDEDPPI3K_1B_p101PhosphoSitePlus
S121PVPYCsICQELPI3K_1B_p101PhosphoSitePlus
S458LRRAGsLCSPLPI3K_1B_p101PhosphoSitePlus
S432LFKSTsQLVLRPI3K_1B_p101PhosphoSitePlus
S447SLEGSsDTALPPI3K_1B_p101PhosphoSitePlus
S440VLRRDsRSLEGPI3K_1B_p101PhosphoSitePlus

Dephosphorylation site
PI3R5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000392812A16SCOSMICSkin Cancer21984974
ENSP00000392812D51NCOSMICSkin Cancer21984974
ENSP00000392812R28CCOSMICIntestines Cancer16959974
ENSP00000392812R28CHPIColorectal Cancer16959974
ENSP00000392812R67PCOSMICBreast Cancer20668451

Differential expressed protein
PI3R5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PI3R5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PI3R5_HUMANAKT3_HUMANkinase -> substrateKEGG
KSYK_HUMANPI3R5_HUMANkinase -> substrateKEGG
JAK1_HUMANPI3R5_HUMANkinase -> substrateKEGG
FYV1_HUMANPI3R5_HUMANenzyme catalysisKEGG
PI3R5_HUMANPI51C_HUMANenzyme catalysisKEGG
PI3R5_HUMANFYV1_HUMANenzyme catalysisKEGG
PTEN_HUMANPI3R5_HUMANenzyme catalysisKEGG
PI3R5_HUMANPTEN_HUMANenzyme catalysisKEGG
PI3R5_HUMANBTK_HUMANenzyme catalysisKEGG
PI3R5_HUMANPLCG1_HUMANenzyme catalysisKEGG
PI3R5_HUMANPLCD3_HUMANenzyme catalysisKEGG
PI51C_HUMANPI3R5_HUMANenzyme catalysisKEGG
CDIPT_HUMANPI3R5_HUMANenzyme catalysisKEGG
PLCD3_HUMANPI3R5_HUMANenzyme catalysisKEGG
PI3R5_HUMANMTM1_HUMANenzyme catalysisKEGG
PI3R5_HUMANI5P2_HUMANenzyme catalysisKEGG
PI3R5_HUMANINP4A_HUMANenzyme catalysisKEGG
PI3R5_HUMANSHIP1_HUMANenzyme catalysisKEGG
INP4A_HUMANPI3R5_HUMANenzyme catalysisKEGG
PI3R5_HUMANPI42A_HUMANenzyme catalysisKEGG
PI4KA_HUMANPI3R5_HUMANenzyme catalysisKEGG
IGF1_HUMANPI3R5_HUMANotherKEGG
PI3R5_HUMANPDPK1_HUMANotherKEGG
IRS1_HUMANPI3R5_HUMANotherKEGG
PI3R5_HUMANKPCI_HUMANotherKEGG
PI3R5_HUMANRAC1_HUMANotherKEGG
PI3R5_HUMANAKT3_HUMANotherKEGG
FAK1_HUMANPI3R5_HUMANotherKEGG
GAB1_HUMANPI3R5_HUMANotherKEGG
ERBB3_HUMANPI3R5_HUMANotherKEGG
PI3R5_HUMANILK_HUMANotherKEGG
EGFR_HUMANPI3R5_HUMANotherKEGG
ICOS_HUMANPI3R5_HUMANotherKEGG
RASH_HUMANPI3R5_HUMANotherKEGG
PI3R5_HUMANMTOR_HUMANotherKEGG
CD19_HUMANPI3R5_HUMANotherKEGG
VAV3_HUMANPI3R5_HUMANotherKEGG
RASK_HUMANPI3R5_HUMANotherKEGG
RAC1_HUMANPI3R5_HUMANotherKEGG
RRAS2_HUMANPI3R5_HUMANotherKEGG
VGFR2_HUMANPI3R5_HUMANotherKEGG
SRC_HUMANPI3R5_HUMANotherKEGG
PI3R5_HUMANVAV3_HUMANotherKEGG
CD28_HUMANPI3R5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa04930Type II diabetes mellitus
hsa05215Prostate cancer
hsa04670Leukocyte transendothelial migration
hsa05164Influenza A
hsa04012ErbB signaling pathway
hsa04725Cholinergic synapse
hsa04070Phosphatidylinositol signaling system
hsa04914Progesterone-mediated oocyte maturation
hsa05211Renal cell carcinoma
hsa04660T cell receptor signaling pathway
hsa04380Osteoclast differentiation
hsa04662B cell receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa04370VEGF signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05146Amoebiasis
hsa04973Carbohydrate digestion and absorption
hsa04664Fc epsilon RI signaling pathway
hsa05218Melanoma
hsa05223Non-small cell lung cancer
hsa04510Focal adhesion
hsa05100Bacterial invasion of epithelial cells
hsa04722Neurotrophin signaling pathway
hsa05222Small cell lung cancer
hsa04620Toll-like receptor signaling pathway
hsa05200Pathways in cancer
hsa04960Aldosterone-regulated sodium reabsorption
hsa05213Endometrial cancer
hsa04150mTOR signaling pathway
hsa04210Apoptosis
hsa04910Insulin signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05166HTLV-I infection
hsa05214Glioma
hsa05160Hepatitis C
hsa05203Viral carcinogenesis
hsa04062Chemokine signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04666Fc gamma R-mediated phagocytosis
hsa05162Measles
hsa04810Regulation of actin cytoskeleton
hsa05210Colorectal cancer
hsa05145Toxoplasmosis
hsa05221Acute myeloid leukemia

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0005942phosphatidylinositol 3-kinase complexIEAcellular_component
GO:0014065phosphatidylinositol 3-kinase cascadeISSbiological_process
GO:0043406positive regulation of MAP kinase activityISSbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:00059441-phosphatidylinositol-4-phosphate 3-kinase, classISScellular_component
GO:00469351-phosphatidylinositol-3-kinase regulator activityIEAmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0030168platelet activationTASbiological_process
GO:0031683G-protein beta/gamma-subunit complex bindingISSmolecular_function
GO:0051897positive regulation of protein kinase B signaling ISSbiological_process
GO:0043551regulation of phosphatidylinositol 3-kinase activiIEAbiological_process
GO:0016020membraneISScellular_component
GO:0005737cytoplasmISScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0005634nucleusIEAcellular_component


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