UniProt/SwissProt ID: | PLCD3_HUMAN |
Description: | phospholipase C, delta 3 [Source:HGNC Symbol;Acc:9061] |
Location: | chr17 q21.31 |
Node attribute: | Enzyme(source); Enzyme(target); PPI(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S105 | IPRAPsQHIFF | HPRD; phosphoELM; SysPTM | |
S496 | DGRALsDREEE | HPRD; phosphoELM; SysPTM | |
S200 | DSNQDsKMSFK | HPRD | |
Dephosphorylation site |
PLCD3_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000313731 | Q457H | COSMIC | Ovarian Cancer | 20668451 |
Differential expressed protein |
PLCD3_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
PLCD3_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa01100 | Metabolic pathways |
hsa04020 | Calcium signaling pathway |
hsa04070 | Phosphatidylinositol signaling system |
hsa00562 | Inositol phosphate metabolism |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | biological_process |
GO:0004871 | signal transducer activity | IEA | molecular_function |
GO:0032154 | cleavage furrow | IEA | cellular_component |
GO:0035556 | intracellular signal transduction | IEA | biological_process |
GO:0004435 | phosphatidylinositol phospholipase C activity | IEA | molecular_function |
GO:0005509 | calcium ion binding | IEA | molecular_function |
GO:0005543 | phospholipid binding | IEA | molecular_function |
GO:0016042 | lipid catabolic process | IEA | biological_process |
GO:0001525 | angiogenesis | IEA | biological_process |
GO:0042127 | regulation of cell proliferation | IEA | biological_process |
GO:0008081 | phosphoric diester hydrolase activity | IEA | molecular_function |
GO:0007165 | signal transduction | IEA | biological_process |
GO:0016020 | membrane | IEA | cellular_component |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0005829 | cytosol | IEA | cellular_component |
GO:0060716 | labyrinthine layer blood vessel development | IEA | biological_process |