Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IGF1_HUMAN
Description:insulin-like growth factor 1 (somatomedin C) [Source:HGNC Symbol;Acc:5464]
Location:chr12 q23.2
Node attribute:PPI(target); ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S184RREIGsRNAECPhosphoSitePlus
Y135PKTQKyQPPSTPhosphoSitePlus

Dephosphorylation site
IGF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337612V22MCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
IGF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IGF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IGF1_HUMANIGF1R_HUMANligand -> receptorHPMR
IGF1_HUMANPI3R5_HUMANotherKEGG
IBP3_HUMANIGF1_HUMANotherKEGG
IGF1_HUMANMK01_HUMANotherKEGG
IGF1_HUMANKS6A6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa04114Oocyte meiosis
hsa04510Focal adhesion
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04960Aldosterone-regulated sodium reabsorption
hsa04115p53 signaling pathway
hsa04150mTOR signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa04730Long-term depression
hsa04914Progesterone-mediated oocyte maturation
hsa05214Glioma
hsa05218Melanoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045445myoblast differentiationIDAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0034392negative regulation of smooth muscle cell apoptotiIDAbiological_process
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0010001glial cell differentiationIEAbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0030166proteoglycan biosynthetic processIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0045725positive regulation of glycogen biosynthetic proceIDAbiological_process
GO:0006260DNA replicationTASbiological_process
GO:0010613positive regulation of cardiac muscle hypertrophyIDAbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIEAbiological_process
GO:0040014regulation of multicellular organism growthIEPbiological_process
GO:0060426lung vasculature developmentIEAbiological_process
GO:0005179hormone activityIDAmolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0046579positive regulation of Ras protein signal transducIDAbiological_process
GO:0046326positive regulation of glucose importIDAbiological_process
GO:0060509Type I pneumocyte differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0043388positive regulation of DNA bindingIDAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0045821positive regulation of glycolysisIDAbiological_process
GO:2000288positive regulation of myoblast proliferationIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0035630bone mineralization involved in bone maturationIDAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIDAbiological_process
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0014834satellite cell maintenance involved in skeletal muIDAbiological_process
GO:0014904myotube cell developmentIDAbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060741prostate gland stromal morphogenesisIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0048839inner ear developmentIEAbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0060510Type II pneumocyte differentiationIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0001501skeletal system developmentTASbiological_process
GO:0005178integrin bindingIDAmolecular_function
GO:0002576platelet degranulationTASbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0051450myoblast proliferationIDAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005159insulin-like growth factor receptor bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0014896muscle hypertrophyIMPbiological_process
GO:0045740positive regulation of DNA replicationISSbiological_process
GO:0051246regulation of protein metabolic processIEAbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0005159insulin-like growth factor receptor bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0060527prostate epithelial cord arborization involved in IEAbiological_process
GO:0090201negative regulation of release of cytochrome c froISSbiological_process
GO:0048468cell developmentIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIDAbiological_process
GO:0016942insulin-like growth factor binding protein complexICcellular_component
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0021940positive regulation of cerebellar granule cell preIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0007517muscle organ developmentTASbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0042104positive regulation of activated T cell proliferatIDAbiological_process
GO:0030104water homeostasisIEAbiological_process
GO:0060766negative regulation of androgen receptor signalingIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0050650chondroitin sulfate proteoglycan biosynthetic procIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioIDAbiological_process
GO:0070886positive regulation of calcineurin-NFAT signaling IDAbiological_process
GO:0005158insulin receptor bindingIPImolecular_function
GO:0030168platelet activationTASbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0043568positive regulation of insulin-like growth factor IDAbiological_process
GO:0033160positive regulation of protein import into nucleusIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0009441glycolate metabolic processTASbiological_process
GO:0032878regulation of establishment or maintenance of cellIEAbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0060736prostate gland growthIEAbiological_process
GO:0060463lung lobe morphogenesisIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIDAbiological_process
GO:0031017exocrine pancreas developmentIEAbiological_process