| UniProt/SwissProt ID: | ICOS_HUMAN |
| Description: | inducible T-cell co-stimulator [Source:HGNC Symbol;Acc:5351] |
| Location: | chr2 q33.2 |
| Node attribute: | PPI(target); PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y180 | DPNGEyMFMRA | PhosphoSitePlus | |
| Dephosphorylation site |
| ICOS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ICOS_HUMAN do not have mutation site. |
| Differential expressed protein |
| ICOS_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ICOS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ICOSL_HUMAN | ICOS_HUMAN | other | KEGG |
| ICOS_HUMAN | PI3R5_HUMAN | other | KEGG |
| ICOS_HUMAN | CD40L_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04672 | Intestinal immune network for IgA production |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04660 | T cell receptor signaling pathway |
| hsa05340 | Primary immunodeficiency |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0002517 | T cell tolerance induction | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0016337 | cell-cell adhesion | IEA | biological_process |
| GO:0006955 | immune response | NAS | biological_process |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0031295 | T cell costimulation | IEA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |